Biology:ADGRF5
From HandWiki
Short description: Protein-coding gene found in humans
 Generic protein structure example |
Adhesion G protein-coupled receptor F5 is a protein that in humans is encoded by the ADGRF5 gene (previously GPR116).[1][2][3] ADGRF5 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.[4][5] It functions as a receptor for soluble FNDC4, an anti-inflammatory protein that is also involved in systematic glucose tolerance.[6]
References
- ↑ Adhesion-GPCRs: structure to function. New York: Springer Science+Business Media. 2010. ISBN 978-1-4419-7912-4.
- ↑ "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters 531 (3): 407–414. November 2002. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
- ↑ "Entrez Gene: GPR116 G protein-coupled receptor 116". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=221395.
- ↑ "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports 3 (5): 1457–1464. May 2013. doi:10.1016/j.celrep.2013.04.019. PMID 23684610.
- ↑ "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE 8 (7). 2013. doi:10.1371/journal.pone.0069451. PMID 23922714. Bibcode: 2013PLoSO...869451F.
- ↑ "Q8IZF2 · AGRF5_HUMAN". UniProt consortium. https://www.uniprot.org/uniprotkb/Q8IZF2/entry.
Further reading
- "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America 100 (8): 4903–4908. April 2003. doi:10.1073/pnas.0230374100. PMID 12679517. Bibcode: 2003PNAS..100.4903V.
- "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics 84 (1): 23–33. July 2004. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
- "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–2144. October 2004. doi:10.1101/gr.2576704. PMID 15489336.
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