Biology:ADGRG4

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Short description: Protein-coding gene in humans

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Adhesion G protein-coupled receptor G4 is a protein that in humans is encoded by the ADGRG4 gene (previously GPR112).[1][2] ADGRG4 is a member of the adhesion GPCR family.[3][4] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[5]

ADGRG4 is expressed in human enterochromaffin cells[6] and in the mouse intestine.[7] The N-terminal fragment (NTF) of ADGRG4 contains pentraxin (PTX)-like modules.[7] ADGRG4 gene expression has been identified as a marker for neuroendocrine carcinoma cells.[6]

References

  1. ↑ "Entrez Gene: GPR112 G protein-coupled receptor 112". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=139378. 
  2. ↑ "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–367. April 2015. doi:10.1124/pr.114.009647. PMID 25713288. 
  3. ↑ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4. 
  4. ↑ "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling 6 (276): re3. May 2013. doi:10.1126/scisignal.2003825. PMID 23695165. 
  5. ↑ "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–1378. March 2012. doi:10.1038/emboj.2012.26. PMID 22333914. 
  6. ↑ 6.0 6.1 "Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas". Modern Pathology 22 (2): 261–272. February 2009. doi:10.1038/modpathol.2008.174. PMID 18953328. 
  7. ↑ 7.0 7.1 "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–367. Apr 2015. doi:10.1124/pr.114.009647. PMID 25713288. 



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