Biology:ADGRG5

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Adhesion G protein-coupled receptor G5 is a protein that in humans is encoded by the ADGRG5 gene (previously GPR114).[1][2][3] The ADGRG5 protein is a member of the adhesion GPCR family.[4][5] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[6]

Tissue distribution

ADGRG5 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells.[7]

Signaling

The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of ADGRG5 to Gαs protein.[8]

References

  1. ↑ "Entrez Gene: GPR114 G protein-coupled receptor 114". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=221188. 
  2. ↑ "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters 531 (3): 407–414. November 2002. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. Bibcode: 2002FEBSL.531..407F. 
  3. ↑ "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–367. April 2015. doi:10.1124/pr.114.009647. PMID 25713288. 
  4. ↑ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4. 
  5. ↑ "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling 6 (276): re3. May 2013. doi:10.1126/scisignal.2003825. PMID 23695165. 
  6. ↑ "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–1378. March 2012. doi:10.1038/emboj.2012.26. PMID 22333914. 
  7. ↑ "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–367. Apr 2015. doi:10.1124/pr.114.009647. PMID 25713288. 
  8. ↑ "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters 586 (8): 1214–1219. April 2012. doi:10.1016/j.febslet.2012.03.014. PMID 22575658. Bibcode: 2012FEBSL.586.1214G. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Biology:ADGRG5&oldid=4662227"