Biology:Frizzled-3

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Frizzled-3 (Fz-3) is a protein that in humans is encoded by the FZD3 gene.[1][2][3]

Function

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.[3]

The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.[4][5]

See also

References

  1. "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21". Biochem Biophys Res Commun 271 (1): 8–14. Jun 2000. doi:10.1006/bbrc.2000.2578. PMID 10777673. 
  2. "Identification, gene structure, and expression of human frizzled-3 (FZD3)". Biochem Biophys Res Commun 273 (1): 27–34. Jul 2000. doi:10.1006/bbrc.2000.2882. PMID 10873558. 
  3. 3.0 3.1 "Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7976. 
  4. "Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons". eLife 2: e01482. Dec 2013. doi:10.7554/eLife.01482. PMID 24347548. 
  5. "Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system". Proc Natl Acad Sci U S A 111 (29): E3005-14. Jul 2014. doi:10.1073/pnas.1406399111. PMID 24799694. Bibcode2014PNAS..111E3005H. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.