Biology:Leukotriene B4 receptor 1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene.

See also

• Eicosanoid receptor
• Etalocib, an antagonist at the leukotriene B4 receptor

Further reading

• "New members of the chemokine receptor gene family.". J. Leukoc. Biol. 59 (1): 18–23. 1996. doi:10.1002/jlb.59.1.18. PMID 8558062. 
• "BLT1 and BLT2: the leukotriene B(4) receptors.". Prostaglandins Leukot. Essent. Fatty Acids 69 (2–3): 123–34. 2004. doi:10.1016/S0952-3278(03)00073-5. PMID 12895595. 
• "Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation.". Allergology International 55 (2): 91–7. 2006. doi:10.2332/allergolint.55.91. PMID 17075244. 
• "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. 1997. doi:10.1101/gr.6.9.807. PMID 8889549. 
• "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.". Nature 387 (6633): 620–4. 1997. doi:10.1038/42506. PMID 9177352. Bibcode: 1997Natur.387..620Y. 
• "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.". Biochem. Biophys. Res. Commun. 237 (2): 297–302. 1997. doi:10.1006/bbrc.1997.7135. PMID 9268704. 
• "Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits.". Biochem. J. 335 (1): 15–8. 1998. doi:10.1042/bj3350015. PMID 9742207. 
• "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene.". J. Exp. Med. 192 (3): 413–20. 2000. doi:10.1084/jem.192.3.413. PMID 10934229. 
• "A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.". J. Exp. Med. 192 (3): 421–32. 2000. doi:10.1084/jem.192.3.421. PMID 10934230. 
• "Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival.". J. Immunol. 168 (7): 3570–6. 2002. doi:10.4049/jimmunol.168.7.3570. PMID 11907121. 
• "Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization.". J. Biol. Chem. 277 (35): 31567–76. 2002. doi:10.1074/jbc.M202723200. PMID 12077128. 
• "5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue.". Am. J. Pathol. 161 (2): 421–8. 2002. doi:10.1016/S0002-9440(10)64198-3. PMID 12163367. 
• "Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release.". J. Biol. Chem. 277 (47): 44898–904. 2003. doi:10.1074/jbc.M208051200. PMID 12244116. 
• "Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.". Clin. Cancer Res. 8 (10): 3232–42. 2003. PMID 12374694. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "In Vivo Chemotaxis Using Cho Cells Expressing Human Leukotriene B4 Receptor". Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology. 507. 2003. pp. 357–61. doi:10.1007/978-1-4615-0193-0_55. ISBN 978-1-4613-4960-0. 

External links

• "Leukotriene Receptors: BLT₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2340. 
• LTB4R+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Receptors,+Leukotriene+B4 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.