Biology:LGR4
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.[1][2] LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.
Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).
References
- ↑ "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet 89 (1–2): 2–5. Aug 2000. doi:10.1159/000015576. PMID 10894923.
- ↑ "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55366.
Further reading
- "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. 1999. doi:10.1210/me.12.12.1830. PMID 9849958.
- "Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor". Biochem. Biophys. Res. Commun. 282 (3): 757–64. 2001. doi:10.1006/bbrc.2001.4625. PMID 11401528.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
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