Biology:VN1R1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Vomeronasal type-1 receptor 1 is a protein that in humans is encoded by the VN1R1 gene.[1][2]
Function
Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined.[2]
Ligands
References
- ↑ "A putative pheromone receptor gene expressed in human olfactory mucosa". Nature Genetics 26 (1): 18–9. September 2000. doi:10.1038/79124. PMID 10973240.
- ↑ 2.0 2.1 "Entrez Gene: VN1R1 vomeronasal 1 receptor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57191.
- ↑ Shirokova E, Raguse JD, Meyerhof W, Krautwurst D. The human vomeronasal type-1 receptor family--detection of volatiles and cAMP signaling in HeLa/Olf cells. FASEB J. 2008 May;22(5):1416-25. doi:10.1096/fj.07-9233com PMID 18096815
- ↑ "The smelling of Hedione results in sex-differentiated human brain activity". NeuroImage 113: 365–73. June 2015. doi:10.1016/j.neuroimage.2015.03.029. PMID 25797832.
- ↑ "The Smelling Principle of Vetiver Oil, Unveiled by Chemical Synthesis". Angew Chem Int Ed Engl 60 (11): 5666–5672. Feb 2021. doi:10.1002/anie.202014609. PMID 33315304. (reference 30)
Further reading
- "Characterization of nonfunctional V1R-like pheromone receptor sequences in human". Genome Research 10 (12): 1979–85. December 2000. doi:10.1101/gr.10.12.1979. PMID 11116092.
- "A novel family of candidate pheromone receptors in mammals". Neuron 28 (3): 835–45. December 2000. doi:10.1016/S0896-6273(00)00157-4. PMID 11163270.
- "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters 520 (1–3): 97–101. June 2002. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
- "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates". Proceedings of the National Academy of Sciences of the United States of America 100 (14): 8337–41. July 2003. doi:10.1073/pnas.1331721100. PMID 12826614. Bibcode: 2003PNAS..100.8337Z.
- "Association study of human VN1R1 pheromone receptor gene alleles and gender". Genetic Testing 11 (2): 128–32. 2007. doi:10.1089/gte.2006.0516. PMID 17627382.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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