Biology:Pharmahuasca
Pharmahuasca is a pharmaceutical version of the entheogenic brew ayahuasca. Traditional ayahuasca is made by brewing the MAOI-containing Banisteriopsis caapi vine with a DMT-containing plant, such as Psychotria viridis. Pharmahuasca refers to a similar combination that uses a pharmaceutical MAOI instead of a plant.
N,N-DMT and harmaline or harmine are typically used as components of pharmahuasca.[citation needed] As a rule, the fewer the β-carbolines, the less nausea; the more DMT, the more spectacular the visions.[citation needed] The constituents are put into separate gelatin capsules. The capsules with harmaline/harmine are swallowed first and the capsules containing DMT are taken 15 to 20 minutes later. A synthetic MAOI can be used in place of harmaline and harmine, although caution must be taken when choosing an MAOI.[1] The use of moclobemide, a reversible inhibitor of monoamine oxidase-A (RIMA), has been recorded and is safer than older irreversible MAOIs (such as isocarboxazid) due to its significantly shorter and more selective effects (although it still exhibits a wide range of dangerous drug-drug interactions).[2][3]
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References
- ↑ Ott J. Ayahuasca Analogues: Pangaen Entheogens. Natural Products Co.. 1994. 34
- ↑ Kaasik, Helle; Souza, Rita C. Z.; Zandonadi, Flávia S.; Tófoli, Luís Fernando; Sussulini, Alessandra (2020-09-08). "Chemical Composition of Traditional and Analog Ayahuasca". Journal of Psychoactive Drugs 53 (1): 65–75. doi:10.1080/02791072.2020.1815911. ISSN 2159-9777. PMID 32896230. https://pubmed.ncbi.nlm.nih.gov/32896230/.
- ↑ Ruffell, Simon; Netzband, Nige; Bird, Catherine; Young, Allan H.; Juruena, Mario F.; Ruffell, Simon; Netzband, Nige; Bird, Catherine et al. (2020-07-03). "The pharmacological interaction of compounds in ayahuasca: a systematic review". Brazilian Journal of Psychiatry 42 (6): 646–656. doi:10.1590/1516-4446-2020-0884. ISSN 1516-4446. PMID 32638916.
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