Chemistry:FG5865

From HandWiki

FG5865 is from the diphenylbutylpiperazine class of agents. It is a 5-HT1A agonist and a 5-HT2A antagonist.[1]

It is believed to be an anxiolytic agent with treatment in substance abuse disorders particularly alcoholism.[2][3]

There is evidence to suggest that FG5865 is a SNDRI.[4]

See also

References

  1. ↑ "New drugs for the treatment of experimental alcoholism". Alcohol (Fayetteville, N.Y.) 11 (6): 439–451. 1994. doi:10.1016/0741-8329(94)90064-7. PMID 7865140. 
  2. ↑ "5-HT1A autoreceptor-mediated effects of the amperozide congeners, FG5865 and FG5893, on rat brain 5-hydroxytryptamine neurochemistry in vivo". European Journal of Pharmacology 238 (2–3): 357–367. July 1993. doi:10.1016/0014-2999(93)90867-H. PMID 7691622. 
  3. ↑ "Alcohol intake in high alcohol drinking (HAD) rats is suppressed by FG5865, a novel 5-HT1A agonist/5-HT2 antagonist". Pharmacology Biochemistry and Behavior 53 (1): 33–40. January 1996. doi:10.1016/0091-3057(95)00195-6. PMID 8848457. 
  4. ↑ "Studies of four novel diphenylbutylpiperazinepyridyl derivatives on release and inhibition of reuptake of dopamine, serotonin and noradrenaline by rat brain in vitro". European Journal of Pharmacology 282 (1–3): 131–135. August 1995. doi:10.1016/0014-2999(95)00300-A. PMID 7498267. 



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