Chemistry:FG-5893

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FG-5893 is a chemical from the diphenylbutylpiperazine class of agents. It is a 5-HT1A agonist and a 5-HT2A antagonist.[1]

It is believed to be an anxiolytic agent with potential uses in the treatment of substance abuse disorders particularly alcoholism.[2][3][4]

There is evidence for FG-5893 behaving as a SNDRI:[5]

CNS review:[6]

See also

References

  1. ↑ "New drugs for the treatment of experimental alcoholism". Alcohol (Fayetteville, N.Y.) 11 (6): 439–451. 1994. doi:10.1016/0741-8329(94)90064-7. PMID 7865140. 
  2. ↑ "Preclinical pharmacology of FG5893: a potential anxiolytic drug with high affinity for both 5-HT1A and 5-HT2A receptors". European Journal of Pharmacology 261 (3): 285–94. August 1994. doi:10.1016/0014-2999(94)90119-8. PMID 7813550. 
  3. ↑ "Differential efficacy of serotonergic drugs FG5974, FG5893, and amperozide in reducing alcohol drinking in P rats". Alcohol (Fayetteville, N.Y.) 13 (4): 399–404. 1996. doi:10.1016/0741-8329(96)00061-4. PMID 8836330. 
  4. ↑ "Alcohol intake in high alcohol drinking (HAD) rats is suppressed by FG5865, a novel 5-HT1A agonist/5-HT2 antagonist". Pharmacology, Biochemistry, and Behavior 53 (1): 33–40. January 1996. doi:10.1016/0091-3057(95)00195-6. PMID 8848457. 
  5. ↑ "Studies of four novel diphenylbutylpiperazinepyridyl derivatives on release and inhibition of reuptake of dopamine, serotonin and noradrenaline by rat brain in vitro". European Journal of Pharmacology 282 (1–3): 131–135. August 1995. doi:10.1016/0014-2999(95)00300-A. PMID 7498267. 
  6. ↑ "FG5893: A Potential New Generation Anxiolytic/Antidepressant Drug with High Affinity for 5-HT 1A and 5-HT 2A Receptors". CNS Drug Reviews 2 (4): 363–383. December 1996. doi:10.1111/j.1527-3458.1996.tb00307.x. 



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