Biology:Neuropeptide Y receptor
| neuropeptide Y receptor Y1 | |
|---|---|
| Identifiers | |
| Symbol | NPY1R |
| Alt. symbols | NPYR |
| NCBI gene | 4886 |
| HGNC | 7956 |
| OMIM | 162641 |
| RefSeq | NM_000909 |
| UniProt | P25929 |
| Other data | |
| Locus | Chr. 4 q31.3-q32 |
| neuropeptide Y receptor Y2 | |
|---|---|
| Identifiers | |
| Symbol | NPY2R |
| NCBI gene | 4887 |
| HGNC | 7957 |
| OMIM | 162642 |
| RefSeq | NM_000910 |
| UniProt | P49146 |
| Other data | |
| Locus | Chr. 4 q31 |
| pancreatic polypeptide receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | PPYR1 |
| Alt. symbols | NPY4R, Y4, PP1 |
| NCBI gene | 5540 |
| HGNC | 9329 |
| OMIM | 601790 |
| RefSeq | NM_005972 |
| UniProt | P50391 |
| Other data | |
| Locus | Chr. 10 q11.2 |
| neuropeptide Y receptor Y5 | |
|---|---|
| Identifiers | |
| Symbol | NPY5R |
| NCBI gene | 4889 |
| HGNC | 7958 |
| OMIM | 602001 |
| RefSeq | NM_006174 |
| UniProt | Q15761 |
| Other data | |
| Locus | Chr. 4 q31-q32 |
Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide.[1] These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.[2][3][4][5][6][7]
Activated neuropeptide receptors release the Gi subunit from the heterotrimeric G protein complex. The Gi subunit in turn inhibits the production of the second messenger cAMP from ATP.
Only the crystal structure of Y1 in complex with two antagonist is available.[8]
Types
There are five known mammalian neuropeptide Y receptors designated Y1 through Y5.[9] Four neuropeptide Y receptors each encoded by a different gene have been identified in humans, all of which may represent therapeutic targets for obesity and other disorders.[10][11][12]
Antagonists
- BIBP-3226
- Lu AA-33810
- BIIE-0246
- UR-AK49
References
- ↑ "XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors". Pharmacol. Rev. 50 (1): 143–50. March 1998. PMID 9549761. http://pharmrev.aspetjournals.org/cgi/pmidlookup?view=long&pmid=9549761.
- ↑ Heilig M (August 2004). "The NPY system in stress, anxiety and depression". Neuropeptides 38 (4): 213–24. doi:10.1016/j.npep.2004.05.002. PMID 15337373.
- ↑ Harro J (October 2006). "CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies". Amino Acids 31 (3): 215–30. doi:10.1007/s00726-006-0334-x. PMID 16738800.
- ↑ "Relevance of neuropeptide Y (NPY) in psychiatry". Current Topics in Medicinal Chemistry 7 (17): 1645–59. 2007. doi:10.2174/156802607782341037. PMID 17979774.
- ↑ "Neuropeptide Y as an endogenous antiepileptic, neuroprotective and pro-neurogenic peptide". Recent Patents on CNS Drug Discovery 1 (3): 315–24. November 2006. doi:10.2174/157488906778773689. PMID 18221213.
- ↑ "NPY family of hormones: clinical relevance and potential use in gastrointestinal disease". Current Topics in Medicinal Chemistry 7 (17): 1710–20. 2007. doi:10.2174/156802607782340966. PMID 17979780.
- ↑ "Molecular recognition of the NPY hormone family by their receptors". Nutrition (Burbank, Los Angeles County, Calif.) 24 (9): 907–17. September 2008. doi:10.1016/j.nut.2008.06.025. PMID 18725086.
- ↑ "1 receptor". Nature 556 (7702): 520–524. April 2018. doi:10.1038/s41586-018-0046-x. PMID 29670288.
- ↑ "Molecular evolution of NPY receptor subtypes". Neuropeptides 38 (4): 141–51. 2004. doi:10.1016/j.npep.2004.06.002. PMID 15337367.
- ↑ "Neuropeptide y receptor selective ligands in the treatment of obesity". Endocrine Reviews 28 (6): 664–84. October 2007. doi:10.1210/er.2007-0003. PMID 17785427.
- ↑ MacNeil DJ (2007). "NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs". Current Topics in Medicinal Chemistry 7 (17): 1721–33. doi:10.2174/156802607782341028. PMID 17979781.
- ↑ "NPY Y2 and Y4 receptors selective ligands: promising anti-obesity drugs?". Current Topics in Medicinal Chemistry 7 (17): 1734–42. 2007. doi:10.2174/156802607782340957. PMID 17979782.
External links
- "Neuropeptide Y Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1292.
- Neuropeptide+Y+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
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