Chemistry:7-Chlorotryptamine

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7-Chlorotryptamine (7-chloro-T, 7-CT, or 7-Cl-T; code name PAL-532) is a serotonin receptor agonist and monoamine releasing agent (MRA) of the tryptamine family.[1] It is a pale yellow solid.[2] It is a full agonist of the serotonin 5-HT2A receptor, with an EC50 of 18.8 nM and an Emax of 102%.[1] In addition, it is a serotonin releasing agent (SRA), with EC50 values of 8.03 nM for serotonin, 656 nM for norepinephrine, and 1,330 nM for dopamine in rat brain synaptosomes.[1] The drug is one of the most potent SRAs in vitro known, after 6-fluorotryptamine (6-FT) and naphthylaminopropane (NAP; PAL-287).[1] 7-CT was first described in the scientific literature by 2014.[1]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 "Alpha-ethyltryptamines as dual dopamine-serotonin releasers". Bioorg Med Chem Lett 24 (19): 4754–4758. October 2014. doi:10.1016/j.bmcl.2014.07.062. PMID 25193229. 
  2. ↑ "New synthetic technologies for the construction of heterocycles and tryptamines". Journal of the American Chemical Society 131 (10): 3690–3699 (S28). March 2009. doi:10.1021/ja808692j. PMID 19243142. Bibcode: 2009JAChS.131.3690N. 




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