Chemistry:N-Ethyltryptamine

From HandWiki
Short description: Chemical compound


N-Ethyltryptamine
Clinical data
Other namesNET; NETP; Ethyltryptamine
ATC code
  • None
Legal status
Legal status
  • US: Schedule I (isomer of DMT)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC12H16N2
Molar mass188.274 g·mol−1
3D model (JSmol)
Melting point87 to 88 °C (189 to 190 °F)
  (verify)

N-Ethyltryptamine (NET), also abbreviated as NETP, is a tryptamine that is structurally related to N-methyltryptamine (NMT) and the psychedelic drugs N,N-dimethyltryptamine (DMT) and N,N-diethyltryptamine (DET).[1]

Use and effects

Alexander Shulgin included NET as an entry in his book TiHKAL (Tryptamines I Have Known and Loved).[1] However, he stated that it had been subjected only to modest human trials and that no active dose level had been identified.[1]

Pharmacology

Pharmacodynamics

NMT activities
Target Affinity (Ki, nM)
5-HT1A IA
5-HT2A 38 (EC50)
99% (Emax)
SERT 19a (EC50)
NET 3,862a (EC50)
DAT 6,660a (EC50)
Notes: The smaller the value, the more avidly the drug interacts with the site. Footnotes: a = Neurotransmitter release. Sources: [2]

NET has been found to act as a potent serotonin 5-HT2A receptor full agonist and a selective serotonin releasing agent.[2] It is inactive at the 5-HT1A receptor.[2]

Chemistry

Synthesis

The chemical synthesis of NET has been described.[1]

Analogues

Analogues of NET include N-methyltryptamine (NMT), dimethyltryptamine (DMT), methylethyltryptamine (MET), and diethyltryptamine (DET), among others.[1]

Society and culture

Canada

NET is not a controlled substance in Canada as of 2025.[3]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 NET Entry in TIHKAL
  2. ↑ 2.0 2.1 2.2 "Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes". Psychopharmacology (Berl) 231 (21): 4135–4144. October 2014. doi:10.1007/s00213-014-3557-7. PMID 24800892. 
  3. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:N-Ethyltryptamine&oldid=4244480"