Chemistry:UCD0168

UCD0168 is a serotonin releasing agent (SRA) of the tropane family related to the tryptamines. It is potent, selective, and shows full efficacy as an SRA in serotonin transporter (SERT)-transfected HEK293T cells. This includes selectivity for the SERT over the dopamine transporter (DAT) and norepinephrine transporter (NET). However, the drug also shows substantial interaction with the serotonin 5-HT₃ receptor and the sigma σ₁ and σ₂ receptor (92.5–95.1% binding inhibition, relative to 94.9% at the SERT). The chemical synthesis of UCD0168 has been described. Analogues of UCD0168 have been described, for instance UCD0820, which is a poorly selective SRA with partial releasing efficacy. UCD0168 was first described in the scientific literature by David E. Olson and colleagues at the University of California, Davis (UCD) in 2025.