Biology:TAAR3

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Short description: Human pseudogene


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Putative trace amine-associated receptor 3 (TAAR3) is a human pseudogene with the gene symbol TAAR3P.[1][2][3][4] In other species such as mice, TAAR3 is a functional protein-coding gene that encodes a trace amine-associated receptor protein.

Isobutylamine is a known ligand of TAAR3 in mice associated with sexual behaviour in male mice.[5]

Isopentylamine was identified as a ligand for murine TAAR3 eliciting aversive behavior.[6]

See also

References

  1. Template:HGNC Retrieved 28 November 2019
  2. "Cloning and characterization of additional members of the G protein-coupled receptor family". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1490 (3): 311–23. February 2000. doi:10.1016/s0167-4781(99)00241-9. PMID 10684976. 
  3. "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics 85 (3): 372–85. March 2005. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104. 
  4. "Entrez Gene: TAAR3 trace amine associated receptor 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9288. 
  5. "How Female Mice Attract Males: A Urinary Volatile Amine Activates a Trace Amine-Associated Receptor That Induces Male Sexual Interest". Frontiers in Pharmacology 9: 924. 2018. doi:10.3389/fphar.2018.00924. PMID 30158871. 
  6. "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Current Opinion in Neurobiology 34: 1–7. October 2015. doi:10.1016/j.conb.2015.01.001. PMID 25616211.