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Short description: Chemical compound
5-(Trifluoromethoxy)-DMT![5-TFMO-DMT structure.png](/wiki/images/thumb/5/56/5-TFMO-DMT_structure.png/250px-5-TFMO-DMT_structure.png) |
Clinical data |
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Other names | 5-OCF3-DMT |
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Identifiers |
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N,N-dimethyl-5-(trifluoromethoxy)-1H-Indole-3-ethanamine
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CAS Number | |
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PubChem CID | |
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Chemical and physical data |
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Formula | C13H15F3N2O |
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Molar mass | 272.271 g·mol−1 |
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3D model (JSmol) | |
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CN(C)CCC1=CNC2=CC=C(OC(F)(F)F)C=C21
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InChI=InChI=1S/C13H15F3N2O/c1-18(2)6-5-9-8-17-12-4-3-10(7-11(9)12)19-13(14,15)16/h3-4,7-8,17H,5-6H2,1-2H3 Key:ODQYGFDOWUZNBA-UHFFFAOYSA-N
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5-TFMO-DMT (5-(trifluoromethoxy)-DMT, 5-OCF3-DMT, 5-(trifluoromethoxy)-N,N-dimethyltryptamine) is a psychedelic tryptamine derivative related to drugs such as 5-MeO-DMT and DMT (DMT). It acts as an agonist at the 5-HT2A receptor with an EC50 of 127.2 nM.[1] It was shown to release serotonin (5-HT) from synaptosomal preparations, and to reduce immobility time in the forced-swim test in animal studies, suggesting that it might have antidepressant activity.[1]
See also
References
- ↑ 1.0 1.1 Kruegel AC, "NOVEL TRYPTAMINES AND METHODS OF TREATING MOOD DISORDERS.", WO patent 2022/235927, published 10 November 2022, assigned to Gilgamesh Pharmaceuticals, Inc..
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Psychedelics (5-HT2A agonists) | Benzofurans | |
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Lyserg‐ amides | |
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Phenethyl‐ amines | 2C-x | 25x-NBx | 25x-NB3OMe | |
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25x-NB4OMe | |
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25x-NBF | |
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25x-NBMD | |
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25x-NBOH | |
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25x-NBOMe | |
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Atypical structures | |
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3C-x | |
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4C-x | |
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DOx | |
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HOT-x | |
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MDxx | |
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Mescaline (subst.) | |
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TMAs |
- TMA
- TMA-2
- TMA-3
- TMA-4
- TMA-5
- TMA-6
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Others | |
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Piperazines | |
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Tryptamines | alpha-alkyltryptamines | |
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x-DALT | |
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x-DET | |
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x-DiPT | |
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x-DMT |
- 4,5-DHP-DMT
- 2,N,N-TMT
- 4-AcO-DMT
- 4-HO-5-MeO-DMT
- 4,N,N-TMT
- 4-Propionyloxy-DMT
- 5,6-diBr-DMT
- 5-AcO-DMT
- 5-Bromo-DMT
- 5-MeO-2,N,N-TMT
- 5-MeO-4,N,N-TMT
- 5-MeO-α,N,N-TMT
- 5-MeO-DMT
- 5-N,N-TMT
- 7,N,N-TMT
- α,N,N-TMT
- (Bufotenin) 5-HO-DMT
- DMT
- Norbaeocystin
- (Psilocin) 4-HO-DMT
- (Psilocybin) 4-PO-DMT
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x-DPT | |
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Ibogaine-related | |
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x-MET | |
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x-MiPT | |
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Others | |
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Others | |
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Dissociatives (NMDAR antagonists) | |
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Deliriants (mAChR antagonists) | |
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Others | |
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![Public domain Public domain](/wiki/images/thumb/e/ef/Imbox_license.svg/52px-Imbox_license.svg.png) | Original source: https://en.wikipedia.org/wiki/5-TFMO-DMT. Read more |