Chemistry:25E-NBOH

From HandWiki

25E-NBOH (2C-E-NBOH, NBOH-2C-E) is a derivative of the phenethylamine derived hallucinogen 2C-E. It was first developed by Martin Hansen at the University of Copenhagen in 2010 as a brain imaging agent,[1] but has subsequently been sold as a designer drug, first being identified in Brazil in 2018 on seized blotter paper,[2][3][4] as well as in Slovenia[5] and France.[6] It acts as a potent serotonin receptor agonist with similar affinity to better-known compounds such as 25I-NBOMe at 5-HT2A and 5-HT2C receptors.[7]

Society and culture

Canada

25E-NBOH is a controlled substance in Canada under phenethylamine blanket-ban language.[8]

United Kingdom

This substance is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause in the Misuse of Drugs Act 1971.[9]


United States

25E-NBOH is not an explicitly controlled substance in the United States.[10] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

References

  1. ↑ Hansen M (2010-12-16). Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain (Ph.D. thesis). University of Copenhagen. doi:10.13140/RG.2.2.33671.14245.
  2. ↑ "Profile of new psychoactive substances (NPS) and other synthetic drugs in seized materials analysed in a Brazilian forensic laboratory.". Forensic Toxicology 37 (1): 265–71. January 2019. doi:10.1007/s11419-018-0456-3. 
  3. ↑ "Identification of new NBOH drugs in seized blotter papers: 25B-NBOH, 25C-NBOH, and 25E-NBOH.". Forensic Toxicology 38 (1): 203–15. January 2020. doi:10.1007/s11419-019-00509-7. 
  4. ↑ "Triple quadrupole-mass spectrometry protocols for the analysis of NBOMes and NBOHs in blotter papers". Forensic Science International 309. April 2020. doi:10.1016/j.forsciint.2020.110184. PMID 32086005. 
  5. ↑ Analytical Report. 25E-NBOH. Nacionalni Forenzični Laboratorij, Slovenia, 24 January 2018
  6. ↑ "Severe 25E-NBOH intoxication associated with MDPHP intake: a case report, metabolism study, and literature review". International Journal of Legal Medicine 138 (3): 815–822. May 2024. doi:10.1007/s00414-023-03151-6. PMID 38117418. https://hal.science/hal-04411455v1/file/Pelletier%20et%20al-2023-Severe%2025E-NBOH%20intoxication%20associated%20with%20MDPHP%20intake.pdf. 
  7. ↑ "Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists". ACS Chemical Neuroscience 5 (3): 243–9. March 2014. doi:10.1021/cn400216u. PMID 24397362. 
  8. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 
  9. ↑ "The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014" (in en). http://www.legislation.gov.uk/uksi/2014/1106/made. 
  10. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf 



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