Chemistry:2-Bromomescaline

From HandWiki

2-Bromomescaline (2-BM or 2-Br-M), also known as 2-bromo-3,4,5-trimethoxyphenethylamine, is a putative psychedelic drug of the scaline family and derivative of the phenethylamine hallucinogen mescaline which has an unusual 2-bromo substitution.[1][2][3] It is an agonist for serotonin receptors, with a binding affinity of 215 nM at 5-HT1A, 513 nM at 5-HT2A and 379 nM at 5-HT2C, so while it is around 10 times more tightly binding than mescaline at 5-HT1A and 5-HT2A receptors, it is over 20 times more potent at 5-HT2C.[2] The drug was 5-fold more potent in substituting for LSD than mescaline in rats.[2] It is not known to have been tested in humans.[2] 2-Bromomescaline was first described in the scientific literature, as a chemical intermediate, in 1972.[2] It has been reported as a designer drug, first identified in Austria in January 2023.[4] The drug is not a controlled substance in Canada as of 2025.[5]

See also

References

  1. ↑ The Shulgin Index. Volume 1. Psychedelic Phenethylamines and Related Compounds. Transform Press. 2011. pp. 280–281, 355. ISBN 978-0-9630096-3-0. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Phenethylamine Von der Struktur zur Funktion. Nachtschatten Verlag AG. 2013. pp. 907–910. ISBN 978-3-03788-700-4. 
  3. ↑ "A novel synthesis of aromatic methoxy and methylenedioxy substituted 2,3,4,5-tetrahydro-1H3-benzazepines". Journal of Heterocyclic Chemistry 9 (3): 609–616. June 1972. doi:10.1002/jhet.5570090322. 
  4. ↑ "New psychoactive substances - the current situation in Europe". European Drug Report. European Union Drugs Agency (EUDA). 2024. https://www.euda.europa.eu/sites/default/files/pdf/31883_en.pdf?606797. 
  5. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:2-Bromomescaline&oldid=4308718"