Chemistry:8A-PDHQ
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Short description: Chemical compound
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| Formula | C15H21N |
| Molar mass | 215.340 g·mol−1 |
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8a-Phenyldecahydroquinoline (8A-PDHQ) is a high affinity NMDA antagonist developed by a team at Parke Davis in the 1950s.[1] It is a structural analog of phencyclidine with slightly lower binding affinity than the parent compound. (−)-8a-Phenyldecahydroquinoline has an in vivo potency comparable to that of (+)-MK-801.[2][3]
References
- ↑ US Patent 3035059
- ↑ "Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency". Journal of Medicinal Chemistry 35 (9): 1634–8. May 1992. doi:10.1021/jm00087a020. PMID 1315871.
- ↑ "Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode". Journal of Molecular Modeling 8 (2): 65–72. February 2002. doi:10.1007/s00894-001-0067-4. PMID 12032600.
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