Chemistry:DOB-FLY

From HandWiki

DOB-FLY, also known as 3C-B-FLY, is a psychedelic drug and designer drug of the phenethylamine, DOx, and FLY families that was developed by David E. Nichols and colleagues at Purdue University. It can be regarded as the α-methyl derivative of 2C-B-FLY or the partially saturated counterpart of Bromo-DragonFLY. Unlike Bromo-DragonFLY, DOB-FLY is only slightly more potent than DOB itself, with an active dose in humans of around 1 mg.[1][2][3][4][5][6] It is a controlled substance in Canada under phenethylamine blanket-ban language,[7] but is not explicitly controlled in the United States.[8]

See also

References

  1. ↑ "A novel (benzodifuranyl)aminoalkane with extremely potent activity at the 5-HT2A receptor". Journal of Medicinal Chemistry 41 (26): 5148–9. December 1998. doi:10.1021/jm9803525. PMID 9857084. 
  2. ↑ "Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity". Bioorganic & Medicinal Chemistry Letters 17 (11): 2998–3002. June 2007. doi:10.1016/j.bmcl.2007.03.073. PMID 17419053. 
  3. ↑ "The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands". Bioorganic & Medicinal Chemistry 16 (8): 4661–9. April 2008. doi:10.1016/j.bmc.2008.02.033. PMID 18296055. 
  4. ↑ "'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines". Bioorganic & Medicinal Chemistry 16 (11): 6242–51. June 2008. doi:10.1016/j.bmc.2008.04.030. PMID 18467103. 
  5. ↑ "Simultaneous analysis of six novel hallucinogenic (tetrahydrobenzodifuranyl) aminoalkanes (FLYs) and (benzodifuranyl) aminoalkanes (DragonFLYs) by GC-MS, LC-MS, and LC-MS-MS.". Forensic Toxicology 28 (1): 9–18. January 2010. doi:10.1007/s11419-009-0083-0. 
  6. ↑ "Comparison of the behavioral responses induced by phenylalkylamine hallucinogens and their tetrahydrobenzodifuran ("FLY") and benzodifuran ("DragonFLY") analogs". Neuropharmacology 144: 368–376. January 2019. doi:10.1016/j.neuropharm.2018.10.037. PMID 30385253. 
  7. ↑ "Controlled Drugs and Substances Act". 5 December 2025. https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 
  8. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf 



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