Chemistry:CE-125

From HandWiki

CE-125 is an analog of modafinil, a member of a series of structurally related heterocyclic derivatives.[1][2]

CE-125 is a selective dopamine reuptake inhibitor, with IC50 of the monoamine transporters being 4.1 ± 0.8 μM at the dopamine transporter (DAT), 687.2 ± 152.8 μM at the norepinephrine transporter (NET), and 436.1 ± 129 μM at the serotonin transporter (SERT). Rats given CE-125 at doses 1 and 10 mg/kg increased the working memory index in a radial arm maze. The compound also altered dopaminergic signaling in rat frontal cortex. D1 receptor protein levels were significantly reduced in trained and treated animals, while D2 receptor levels remained unchanged.[3]

CE-125 and related compounds are studied as potential treatment of motivational disorders and Alzheimer's disease.[1]

See also

References

  1. ↑ 1.0 1.1 "Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease". Frontiers in Cellular Neuroscience 17. 2023. doi:10.3389/fncel.2023.1292858. PMID 38026688. 
  2. ↑ "Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters". Journal of Medicinal Chemistry 63 (1): 391–417. January 2020. doi:10.1021/acs.jmedchem.9b01938. PMID 31841637. 
  3. ↑ "A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat". Behavioural Brain Research 332: 308–315. August 2017. doi:10.1016/j.bbr.2017.06.023. PMID 28629964. 




Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:CE-125&oldid=4644821"