Chemistry:Bradanicline
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| Other names | TC-5619 |
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| Formula | C22H23N3O2 |
| Molar mass | 361.445 g·mol−1 |
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Bradanicline (INN,[1] code name TC-5619) is a drug which was being developed by Targacept that acts as a partial agonist at the α7 subtype of the neural nicotinic acetylcholine receptors. It showed cognitive enhancing effects in animal studies, and was being developed through a collaboration between Targacept and AstraZeneca as a potential treatment for schizophrenia and attention deficit disorder.[2] Phase I clinical trials were completed successfully, and it was in phase II trials.[3]
In May 2011, AstraZeneca declined to exercise its right to license the compound.[4] In September 2012, Targacept ended its development of badanicline for the purpose of treating ADHD in adults.[5] It was being studied for cognitive and memory enhancement.[6]
Bradanicline was discontinued for Alzheimer's disease and cognitive impairment in schizophrenia in late-2013.[7] It was also discontinued for ADHD.[7]
References
- ↑ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 73". World Health Organization. pp. 68–9. https://www.who.int/medicines/publications/druginformation/innlists/RL73.pdf.
- ↑ "TC-5619 Cognitive Dysfunction in Schizophrenia". Catalyst Biosciences. http://www.targacept.com/wt/page/tc_5619.
- ↑ "Rethinking Schizophrenia". Chemical & Engineering News 86 (37): 38–40. September 2008. doi:10.1021/cen-v086n037.p038. http://pubs.acs.org/cen/science/86/8637sci2.html.
- ↑ "Targacept retains full development rights for TC-5619". Fierce Biotech. 2 May 2011. http://www.fiercebiotech.com/press-releases/targacept-retain-full-rights-tc-5619-0.
- ↑ "Targacept ends development of ADHD drug". Market Watch. http://www.marketwatch.com/story/targacept-ends-development-of-adhd-drug-2012-09-17.
- ↑ "Statement on a Nonproprietary Name Adopted by the USAN Council". November 27, 2013. http://www.ama-assn.org//resources/doc/usan/bradanicline.pdf.
- ↑ 7.0 7.1 "Bradanicline - Attenua". AdisInsight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800026693.
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