Chemistry:Alpha-Pyrrolidinopentiothiophenone

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Short description: Stimulant drug


alpha-Pyrrolidinopentiothiophenone
Α-PVT.svg
A-PVT.png
Legal status
Legal status
  • DE: Anlage II (Authorized trade only, not prescriptible)
  • UK: Class B
  • Illegal in China, Sweden and Switzerland
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC13H19NOS
Molar mass237.36 g·mol−1
3D model (JSmol)

α-Pyrro​lidino​pentio​thiophenone (also known as α-PVT) is a synthetic stimulant of the cathinone class that has been sold online as a designer drug.[1][2][3] It is an analogue of α-PVP where the phenyl ring has been replaced by thiophene.

α-PVT was first identified in Japan in 2013.[4] Its metabolism has been described in literature.[5][6]

Side effects

α-PVT has been shown to possess high cytotoxicity against human cell lines.[7]

Legality

Sweden's public health agency suggested classifying α-PVT as hazardous substance on November 10, 2014.[8]

(As of October 2015) α-PVT is a controlled substance in China.[9]

α-PVT is illegal in Switzerland (As of December 2015).[10]

See also

References

  1. ↑ "α-Pyrrolidinopentiothiophenone". Cayman Chemical. https://www.caymanchem.com/app/template/Product.vm/catalog/14182. 
  2. ↑ "Simultaneous determination of 40 novel psychoactive stimulants in urine by liquid chromatography-high resolution mass spectrometry and library matching". Journal of Chromatography A 1397 (5): 32–42. June 2015. doi:10.1016/j.chroma.2015.04.002. PMID 25931378. 
  3. ↑ "Identification and characterization of α-PVT, α-PBT, and their bromothienyl analogs found in illicit drug products". Forensic Toxicology 34 (1): 76–93. January 2016. doi:10.1007/s11419-015-0288-3. 
  4. ↑ "Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products". Forensic Toxicology 31 (2): 223–240. July 2013. doi:10.1007/s11419-013-0182-9. 
  5. ↑ "UPLC/ESI-MS/MS-based determination of metabolism of several new illicit drugs, ADB-FUBINACA, AB-FUBINACA, AB-PINACA, QUPIC, 5F-QUPIC and α-PVT, by human liver microsome". Biomedical Chromatography 28 (6): 831–838. June 2014. doi:10.1002/bmc.3155. PMID 24861751. 
  6. ↑ "In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant". Bioanalysis 8 (1): 65–82. January 2016. doi:10.4155/bio.15.237. PMID 26648097. 
  7. ↑ "Cytotoxic Activity of Pyrovalerone Derivatives, an Emerging Group of Psychostimulant Designer Cathinones". Neurotoxicity Research 30 (2): 239–250. August 2016. doi:10.1007/s12640-016-9640-6. PMID 27295059. 
  8. ↑ "Cannabinoider föreslås bli klassade som hälsofarlig vara" (in Swedish). http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/november/cannabinoider-foreslas-bli-klassade-som-halsofarlig-vara/. 
  9. ↑ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. http://www.sfda.gov.cn/WS01/CL0056/130753.html. 
  10. ↑ "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Der Bundesrat. https://www.admin.ch/opc/de/classified-compilation/20101220/index.html. 




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