Chemistry:Mexedrone
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Short description: Stimulant and entactogen drug
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| Formula | C12H17NO2 |
| Molar mass | 207.273 g·mol−1 |
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Mexedrone (also known as 4-MMC-MeO) is a stimulant and an entactogen drug of the cathinone class that has been sold online as a designer drug.[1][2][3][4] It is the alpha-methoxy derivative of Mephedrone.
Pharmacology
Mexedrone acts as a weak serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with IC50 values of 5289 nM, 8869 nM and 6844 nM, respectively, as well as a weak serotonin releasing agent (SRA) with an EC50 value of 2525 nM.[5]
Legal status
Mexedrone is illegal in Sweden as of January 26, 2016[6] as well as Japan as of August 24, 2016.[7]
See also
References
- ↑ "Mexedrone". New Synthetic Drug Database. http://nsddb.eu/substance/528/.
- ↑ "Identification and analytical characterization of four synthetic cathinone derivatives iso-4-BMC, β-TH-naphyrone, mexedrone, and 4-MDMC". Drug Testing and Analysis 9 (2): 274–281. February 2017. doi:10.1002/dta.1983. PMID 27352812.
- ↑ "Spectroscopic characterization and crystal structures of four hydrochloride cathinones: N-ethyl-2-amino-1-phenylhexan-1-one (hexen, NEH), N-methyl-2-amino-1-(4-methylphenyl)-3-methoxypropan-1-one (mexedrone), N-ethyl-2-amino-1-(3,4-methylenedioxyphenyl)pentan-1-one (ephylone) and N-butyl-2-amino-1-(4-chlorophenyl)propan-1-one (4-chlorobutylcathinone)". Forensic Toxicology 37 (2): 456–464. 14 May 2019. doi:10.1007/s11419-019-00477-y.
- ↑ "11 analytically confirmed cases of mexedrone use among polydrug users". Clinical Toxicology 55 (3): 181–186. March 2017. doi:10.1080/15563650.2016.1271424. PMID 28075189.
- ↑ "Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone". Drug Testing and Analysis 9 (3): 358–368. March 2017. doi:10.1002/dta.2053. PMID 27524685.
- ↑ "31 nya ämnen kan klassas som narkotika eller hälsofarlig vara" (in sv). Folkhälsomyndigheten. November 2015. https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2015/november/31-nya-amnen-kan-klassas-som-narkotika-eller-halsofarlig-vara/.
- ↑ "指定薬物一覧" (in Japanese). Ministry of Health, Labour and Welfare. http://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/dl/meisho.pdf.
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