Chemistry:Bisorcic
Bisorcic (INN), also known as N2,N5-diacetyl-L-ornithine, is a drug described as a hepatoprotective agent and "psychostimulant" which has been used in France in the treatment of asthenia.[1][2][3][4][5] It is the N2,N5-diacetylated derivative of the amino acid L-ornithine.[6]
Bisorcic was first described in the literature in 1973 in a German patent.[1] The INN was designated around 1975.[7] The drug was marketed in France by Astyl-Gallier in 1987.[5] It was provided in the form of 200 mg oral capsules and four capsules were taken daily.[5]
L-Ornithine, as the combination drug L-ornithine L-aspartate (LOLA), has been used in the treatment of hepatic encephalopathy and cirrhosis and is likewise described as hepatoprotective.[8][9] It is thought to work by participating in the urea cycle and lowering ammonia levels.[8][9]
References
- ↑ 1.0 1.1 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. 2014. p. 906. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA906. Retrieved 28 September 2024. "Nα,Nδ-Di-Ac: [39825-23-5]. N2,N5-Diacetylornithine, 9Cl. Bisorcic, INN. 69H16N2O4. M 216,236. Hepatoprotective agent, psychostimulant. [...] Ger. Pat., 2 219 874, (1973); CA, 78, 98010t (Bisorcic)."
- ↑ Dictionary of Natural Products. CRC Press. 2020. p. 356. ISBN 978-1-000-15302-6. https://books.google.com/books?id=YJgFEAAAQBAJ&pg=PA356. Retrieved 28 September 2024.
- ↑ Dictionary of Marine Natural Products with CD-ROM. CRC Press. 2007. p. 522. ISBN 978-0-8493-8217-8. https://books.google.com/books?id=w1bLBQAAQBAJ&pg=PA522. Retrieved 28 September 2024.
- ↑ Organic-chemical Drugs and Their Synonyms: (an International Survey). Akademie Verlag. 1994. p. 359. ISBN 978-3-05-500156-7. https://books.google.com/books?id=1ghtAAAAMAAJ. Retrieved 28 September 2024. "6220. 39825-23-5 CI CI -NH2 N C10H10CI2N2O2 51 230-28-5. N2,N5-Diacetyl-L-ornithine. R see also no. 3704. S Bisorcic**. U Psychostimulant."
- ↑ 5.0 5.1 5.2 Drugs Available Abroad: A Guide to Therapeutic Drugs Available and Approved for Use Outside the U. S.. Gale Research; Derwent Publications Ltd.. 1990. p. 24. ISBN 978-0-8103-7177-4. https://books.google.com/books?id=2x1tAAAAMAAJ. Retrieved 28 September 2024. "109 BISORCIC. Countries Where Available and Release Dates: France (1987). Brand Names and Manufacturers: Astyl-Gallier (France). Drug Action: Psychostimulant. Indications/Usage: Asthenia. How Supplied: 200 mg capsules. Dosage: 4 capsules daily. Not recommended in children. Contraindications: Epilepsy."
- ↑ "Bisorcic". PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/65977.
- ↑ "Proposed International Nonproprietary Names (Prop. INN): List 34. International Nonproprietary Names for Pharmaceutical Substances.". Supplement to WHO Chronicle 29 (9). 1975. https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl34.pdf. Retrieved 28 September 2024.
- ↑ 8.0 8.1 "Pharmacokinetic and Pharmacodynamic Properties of L-Ornithine L-Aspartate (LOLA) in Hepatic Encephalopathy". Drugs 79 (Suppl 1): 23–29. February 2019. doi:10.1007/s40265-018-1023-2. PMID 30706424.
- ↑ 9.0 9.1 "L-ornithine L-aspartate for prevention and treatment of hepatic encephalopathy in people with cirrhosis". The Cochrane Database of Systematic Reviews 5 (5). May 2018. doi:10.1002/14651858.CD012410.pub2. PMID 29762873.
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