Etifelmine (INN ; also known as gilutensin ) is a stimulant drug. It was used for the treatment of hypotension (low blood pressure).[ 1]
Synthesis
The base-catalyzed reaction between benzophenone (1 ) and butyronitrile (2 ) gives 2-[hydroxy(diphenyl)methyl]butanenitrile (3 ).[ 2] [ 3] 4 ). The tertiary hydroxyl group is dehydrated by treatment with anhydrous hydrogen chloride gas, completing the synthesis of etifelmine (5 ).
Synthesis of etifelmine
See also
References
↑ "The treatment of hypotensive circulatory disorders with gilutensin." (in German). Therapie der Gegenwart 103 : 1007–12. August 1964. PMID 14254672 . ↑ Etifelmine , Thieme↑ Dr Werner Heinrich & Dr Walter Heigel, DE patent 1122514 (1962 to Giulini Gmbh Geb).
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