Chemistry:Etifelmine
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Short description: Stimulant drug used to treat hypotension
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| Formula | C17H19N |
| Molar mass | 237.346 g·mol−1 |
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Etifelmine (INN; also known as gilutensin) is a stimulant drug. It was used for the treatment of hypotension (low blood pressure).[1]
Synthesis
The base catalyzed reaction between benzophenone [119-61-9] (1) and butyronitrile [109-74-0] (2) gives 2-[hydroxy(diphenyl)methyl]butanenitrile [22101-20-8] (3). Catalytic hydrogenation reduces the nitrile group to a primary amine giving 1,1-diphenyl-2-ethyl-3-aminopropanol [22101-87-7] (4). The tertiary hydroxyl group is dehydrated by treatment with anhydrous hydrogen chloride gas, completing the synthesis of Etifelmine (5).
See also
References
- ↑ "The treatment of hypotensive circulatory disorders with gilutensin." (in German). Therapie der Gegenwart 103: 1007–12. August 1964. PMID 14254672.
- ↑ Dr Werner Heinrich & Dr Walter Heigel, DE patent 1122514 (1962 to Giulini Gmbh Geb).
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