Chemistry:Trecadrine

From HandWiki

Trecadrine (INN) is a drug that was originally developed as an anti-ulcer agent but was found to act as a β3-adrenergic receptor agonist with potential anti-obesity and anti-diabetic properties.[1][2][3][4] It is selective for the β3-adrenergic receptor, lacking activity at the β1- and β2-adrenergic receptors.[3] The drug is orally active.[3] Structurally, trecadrine is a substituted β-hydroxyamphetamine and derivative of β-hydroxy-N-methylamphetamine (ephedrine, pseudoephedrine) with a tricyclic moiety attached at the amine.[1][5]

References

  1. ↑ 1.0 1.1 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. 2014. pp. 411,571. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=RA1-PA411. Retrieved 17 October 2024. 
  2. ↑ Drugs: Synonyms and Properties. Wiley. 2002. p. 514. ISBN 978-0-566-08491-1. https://books.google.com/books?id=QxcoEAAAQBAJ&pg=PA514. Retrieved 17 October 2024. 
  3. ↑ 3.0 3.1 3.2 "Orally bioavailable beta 3-adrenergic receptor agonists as potential therapeutic agents for obesity and type-II diabetes". Progress in Medicinal Chemistry 41: 167–194. 2003. doi:10.1016/s0079-6468(02)41005-3. ISBN 978-0-444-51142-3. PMID 12774694. 
  4. ↑ "-drine sympathomimetics". The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances 2018 (Stem Book 2018). World Health Organization. https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/stembook-2018.pdf#page=95. 
  5. ↑ "CID 65823". PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/65823. 



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