Chemistry:2C-T-29

From HandWiki

2C-T-29, also known as 2C-T-PARGY or 2C-T-PROPARGYL or as 4-propargylthio-2,5-dimethoxyphenethylamine, is a designer drug from the substituted phenethylamine family, which was first synthesised by Josh Hartsel and colleagues in 2024. It is a potent agonist at the serotonin receptor 5-HT2A in vitro, with a binding affinity (Ki) of 1.3 nM and an EC50 of 0.67 nM, acting as a full agonist.[1] While the closely related propylthio compound 2C-T-7 and the allylthio derivative 2C-T-16 are both known to be potent psychedelic drugs in humans, the propargylthio analogue 2C-T-29 is not known to have been tested in humans or other animals.[2] It is a controlled substance in Canada under phenethylamine blanket-ban language.[3]

See also

References

  1. ↑ "Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT2 Receptor Agonist". Journal of Medicinal Chemistry 67 (8): 6144–6188. April 2024. doi:10.1021/acs.jmedchem.3c01961. PMID 38593423. 
  2. ↑ Phenethylamine Von der Struktur zur Funktion. Nachtschatten Verlag AG. 2013. pp. 792–795. ISBN 978-3-03788-700-4. 
  3. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 



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