Chemistry:Propylcathinone

Propylcathinone (code name PAL-359), or N-propylcathinone, is a stimulant and designer drug of the amphetamine and cathinone families.^[1]^[2]^[3] It is known to be inactive as a dopamine reuptake inhibitor and releasing agent.^[3] Nonetheless, the drug substitutes for dextroamphetamine in animal drug discrimination tests.^[1] The related agent propylamphetamine is known to be partially metabolized into amphetamine and this is thought to be involved in its effects.^[4]^[5] Propylcathinone was first encountered as a novel designer drug in Europe by 2015.^[6]^[7]^[2]

References

↑ ^1.0 ^1.1 "Cathinone: an investigation of several N-alkyl and methylenedioxy-substituted analogs". Pharmacology, Biochemistry, and Behavior 58 (4): 1109–1116. December 1997. doi:10.1016/s0091-3057(97)00323-7. PMID 9408221.
↑ ^2.0 ^2.1 "EMCDDA framework and practical guidance for naming cathinones". Drug Testing and Analysis 16 (12): 1409–1435. December 2024. doi:10.1002/dta.3662. PMID 38389255.
↑ ^3.0 ^3.1 "Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter". Drug and Alcohol Dependence 147: 1–19. February 2015. doi:10.1016/j.drugalcdep.2014.12.005. PMID 25548026.
↑ "The effect of N-alkyl chain length of stereochemistry on the absorption, metabolism and during excretion of N-alkylamphetamines in man". The Journal of Pharmacy and Pharmacology 25 (10): 793–799. October 1973. doi:10.1111/j.2042-7158.1973.tb09943.x. PMID 4151673.
↑ "In vitro metabolism of 1-phenyl-2-(n-propylamino) propane (N-propylamphetamine) by rat liver homogenates". The Journal of Pharmacy and Pharmacology 28 (11): 815–821. November 1976. doi:10.1111/j.2042-7158.1976.tb04063.x. PMID 11289.
↑ "2015 Annual Reports on the implementation of Council Decision 2005/387/JHA". 23 October 2018. https://www.europol.europa.eu/publications-events/publications/emcdda%E2%80%93europol-2005-2015-annual-reports-implementation-of-council-decision-2005/387/jha.
↑ "Identification and structural characterization of synthetic cathinones: N-propylcathinone, 2,4-dimethylmethcathinone, 2,4-dimethylethcathinone, 2,4-dimethyl-α-pyrrolidinopropiophenone, 4-bromo-α-pyrrolidinopropiophenone, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one and 2,4-dimethylisocathinone". Forensic Toxicology 37 (2): 288–307. 2019. doi:10.1007/s11419-018-00463-w. ISSN 1860-8965. https://link.springer.com/content/pdf/10.1007/s11419-018-00463-w.pdf. Retrieved 12 March 2025.

External links

Propylcathinone - Isomer Design

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Propylcathinone. Read more

[DalCasonYoungGlennon1997-1] 1.0 ^1.1 "Cathinone: an investigation of several N-alkyl and methylenedioxy-substituted analogs". Pharmacology, Biochemistry, and Behavior 58 (4): 1109–1116. December 1997. doi:10.1016/s0091-3057(97)00323-7. PMID 9408221.

[PulverFischmannGallegos2024-2] 2.0 ^2.1 "EMCDDA framework and practical guidance for naming cathinones". Drug Testing and Analysis 16 (12): 1409–1435. December 2024. doi:10.1002/dta.3662. PMID 38389255.

[ReithBloughHong2015-3] 3.0 ^3.1 "Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter". Drug and Alcohol Dependence 147: 1–19. February 2015. doi:10.1016/j.drugalcdep.2014.12.005. PMID 25548026.

[BeckettShenoy1973-4] "The effect of N-alkyl chain length of stereochemistry on the absorption, metabolism and during excretion of N-alkylamphetamines in man". The Journal of Pharmacy and Pharmacology 25 (10): 793–799. October 1973. doi:10.1111/j.2042-7158.1973.tb09943.x. PMID 4151673.

[CouttsDawsonBeckett1976-5] "In vitro metabolism of 1-phenyl-2-(n-propylamino) propane (N-propylamphetamine) by rat liver homogenates". The Journal of Pharmacy and Pharmacology 28 (11): 815–821. November 1976. doi:10.1111/j.2042-7158.1976.tb04063.x. PMID 11289.

[Europol2018-6] "2015 Annual Reports on the implementation of Council Decision 2005/387/JHA". 23 October 2018. https://www.europol.europa.eu/publications-events/publications/emcdda%E2%80%93europol-2005-2015-annual-reports-implementation-of-council-decision-2005/387/jha.

[BłażewiczBednarekPopławska2019-7] "Identification and structural characterization of synthetic cathinones: N-propylcathinone, 2,4-dimethylmethcathinone, 2,4-dimethylethcathinone, 2,4-dimethyl-α-pyrrolidinopropiophenone, 4-bromo-α-pyrrolidinopropiophenone, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one and 2,4-dimethylisocathinone". Forensic Toxicology 37 (2): 288–307. 2019. doi:10.1007/s11419-018-00463-w. ISSN 1860-8965. https://link.springer.com/content/pdf/10.1007/s11419-018-00463-w.pdf. Retrieved 12 March 2025.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

v t e Phenethylamines
Phenethylamines	Psychedelics: 25B-NBOMe 25C-NBOMe 25D-NBOMe 25I-NBOMe 25N-NBOMe 2C-B 2C-B-AN 2C-Bn 2C-Bu 2C-C 2C-CN 2C-CP 2C-D 2C-E 2C-EF 2C-F 2C-G 2C-G-1 2C-G-2 2C-G-3 2C-G-4 2C-G-5 2C-G-6 2C-G-N 2C-H 2C-I 2C-iP 2C-N 2C-NH2 2C-O 2C-O-4 2C-P 2C-Ph 2C-SE 2C-T 2C-T-2 2C-T-3 2C-T-4 2C-T-5 2C-T-6 2C-T-7 2C-T-8 2C-T-9 2C-T-10 2C-T-11 2C-T-12 2C-T-13 2C-T-14 2C-T-15 2C-T-16 2C-T-17 2C-T-18 2C-T-19 2C-T-20 2C-T-21 2C-T-22 2C-T-22.5 2C-T-23 2C-T-24 2C-T-25 2C-T-27 2C-T-28 2C-T-30 2C-T-31 2C-T-32 2C-T-33 2C-TFE 2C-TFM 2C-YN 2C-V Allylescaline DESOXY Escaline Isoproscaline Jimscaline Macromerine MEPEA Mescaline Metaescaline Methallylescaline Proscaline Psi-2C-T-4 TCB-2 Stimulants: Phenylethanolamine Hordenine Phenethylamine α-Methylphenethylamine (amphetamine) β-Methylphenethylamine m-Methylphenethylamine N-Methylphenethylamine o-Methylphenethylamine p-Methylphenethylamine Methylphenidate Entactogens: Lophophine MDPEA MDMPEA Others: BOH DMPEA
Amphetamines	Psychedelics: 3C-BZ 3C-E 3C-P Aleph Beatrice Bromo-DragonFLY D-Deprenyl DMA DMCPA DMMDA DOB DOC DOEF DOET DOI DOM DON DOPR DOTFM Ganesha MMDA MMDA-2 Psi-DOM TMA TeMA Stimulants: 2-FA 2-FMA 3-FA 3-FMA Acridorex Alfetamine Amfecloral Amfepentorex Amphetamine (Dextroamphetamine, Levoamphetamine) Amphetaminil Benfluorex Benzphetamine Cathine Clobenzorex Dimethylamphetamine Ephedrine Etilamfetamine Fencamfamin Fencamine Fenethylline Fenfluramine (Dexfenfluramine, Levofenfluramine) Fenproporex Flucetorex Fludorex Formetorex Furfenorex Gepefrine 4-Hydroxyamphetamine Iofetamine Isopropylamphetamine Lefetamine Lisdexamfetamine Mefenorex Metaraminol Methamphetamine (Dextromethamphetamine, Levomethamphetamine) Methoxyphenamine MMA Morforex Norfenfluramine L -Norpseudoephedrine N,alpha-Diethylphenylethylamine Oxifentorex Oxilofrine Ortetamine PBA PCA Phenpromethamine PFA PFMA PIA PMA PMEA PMMA Phenylpropanolamine Pholedrine Prenylamine Propylamphetamine Pseudoephedrine Sibutramine Tiflorex Tranylcypromine Xylopropamine Zylofuramine Entactogens: 4-FA 4-FMA 4-MA 4-MMA 4-MTA 5-APB 5-APDB 5-EAPB 5-IT 5-MAPB 5-MAPDB 6-APB 6-APDB 6-Chloro-MDMA 6-EAPB 6-IT 6-MAPB 6-MAPDB EDA IAP 2,3-MDA 3,4-MDA (tenamfetamine) MDEA MDHMA MDMA (midomafetamine) MDOH Methamnetamine MMDMA Naphthylaminopropane TAP Others: 3,4-DCA Amiflamine DiFMDA Selegiline (also D -Deprenyl)
Phentermines	Stimulants: Chlorphentermine Cloforex Clortermine Etolorex Mephentermine Pentorex Phentermine Entactogens: MDPH MDMPH Others: Cericlamine
Cathinones	Stimulants: 3-FMC 4-MC 4-BMC 4-CMC 4-EMC 4-FMC 4-MEC 4-MeMABP 4-MPD Amfepramone Benzedrone Brephedrone Buphedrone Bupropion Cathinone Dimethylcathinone Ethcathinone Eutylone Hydroxybupropion Methcathinone Methedrone NEB N-Ethylhexedrone N-Ethylpentedrone Pentedrone Pentylone Radafaxine Entactogens: 3,4-DMMC 3-MMC Butylone Ethylone Methylone Methylenedioxycathinone Mephedrone
Phenylisobutylamines	Entactogens: 4-CAB 4-MAB Ariadne BDB Butylone EBDB Eutylone MBDB Stimulants: Phenylisobutylamine
Phenylalkylpyrrolidines	Stimulants: α-PBP α-PHP α-PPP α-PVP MDPBP MDPPP MDPV 4-MePBP 4-MePHP 4-MePPP MOPPP MOPVP MPBP MPHP MPPP Naphyrone PEP Prolintane Pyrovalerone
Catecholamines (and close relatives)	6-FNE 6-OHDA a-Me-DA a-Me-TRA Adrenochrome Ciladopa D -DOPA (Dextrodopa) Dimetofrine Dopamine Epinephrine Epinine Etilefrine Ethylnorepinephrine Fenclonine Ibopamine Isoprenaline Isoetarine L -DOPA (Levodopa) L -DOPS (Droxidopa) L -Phenylalanine L -Tyrosine m-Tyramine Metanephrine Metaraminol Metaterol Metirosine Methyldopa N,N-Dimethyldopamine Nordefrin (Levonordefrin) Norepinephrine Norfenefrine (m-Octopamine) Normetanephrine Orciprenaline p-Octopamine p-Tyramine Phenylephrine Synephrine
Miscellaneous	AL-LAD Amidephrine Arbutamine Cafedrine Denopamine Desvenlafaxine Diphenidine Dizocilpine Dobutamine Dopexamine Ephenidine Etafedrine ETH-LAD Famprofazone Fluorolintane Hexapradol IP-LAD Lysergic acid amide Lysergic acid 2-butyl amide Lysergic acid 2,4-dimethylazetidide Lysergic acid diethylamide Methoxamine Methoxphenidine MT-45 PARGY-LAD Phenibut PRO-LAD Pronethalol Salbutamol (Levosalbutamol) Solriamfetol Theodrenaline Thiamphenicol UWA-101

Anonymous

Search

Chemistry:Propylcathinone

Namespaces

More

Page actions

See also

References

External links

Navigation

Navigation

Help

googletranslator

Navigation

Wiki tools

Wiki tools

Anonymous

Search

Chemistry:Propylcathinone

See also

References

External links

Navigation

Wiki tools

Page tools

Other projects

Categories