Chemistry:Propylone
Propylone, also known as 3,4-methylenedioxy-N-propylcathinone is a mixed monoamine releasing agent and reupake inhibitor of the cathinone family related to methylone and ethylone.[1]
It acts specifically as a weak partial serotonin–dopamine releasing agent (SDRA) and serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), with EC50 (Emax) values for induction of monoamine release of 3,128 nM (30%) for serotonin and 976 nM (20%) for dopamine, and IC50 value for monoamine reuptake inhibition of 2,462 nM for serotonin, 28,540 nM for norepinephrine, and 1,863 nM for dopamine.[1]
The drug was first described in the literature in a 1996 patent by Alexander Shulgin and Peyton Jacob III.[2] It was subsequently characterized more thoroughly by 2015[1] and was encountered as a novel designer drug in Europe by 2016.[3][4][5]
See also
- Propylcathinone
- Propylamphetamine
- Butylone
- Ephylone
- Eutylone
- Dimethylone
References
- ↑ 1.0 1.1 1.2 Sakloth F (11 December 2015). Psychoactive synthetic cathinones (or 'bath salts'): Investigation of mechanisms of action. Theses and Dissertations (Ph.D. thesis). Virginia Commonwealth University. doi:10.25772/AY8R-PW77. Retrieved 24 November 2024 – via VCU Scholars Compass.
- ↑ Jacob III P, Shulgin AT, "Preparation of novel N-substituted-2-amino-3′,4′-methylenedioxypropiophenones as anti-depressant and anti-parkinsonism agents.", WO patent 1996039133, published 12 December 1996, assigned to Neurobiological Technologies, Inc.
- ↑ "EMCDDA–Europol 2016 Annual Report on the implementation of Council Decision 2005/387/JHA". 23 October 2018. https://www.europol.europa.eu/publications-events/publications/emcdda%E2%80%93europol-2016-annual-report-implementation-of-council-decision-2005/387/jha.
- ↑ "Identification and analytical characterization of nine synthetic cathinone derivatives N-ethylhexedrone, 4-Cl-pentedrone, 4-Cl-α-EAPP, propylone, N-ethylnorpentylone, 6-MeO-bk-MDMA, α-PiHP, 4-Cl-α-PHP, and 4-F-α-PHP". Drug Test Anal 9 (8): 1162–1171. August 2017. doi:10.1002/dta.2136. PMID 27863142.
- ↑ "EMCDDA framework and practical guidance for naming cathinones". Drug Test Anal 16 (12): 1409–1435. December 2024. doi:10.1002/dta.3662. PMID 38389255.
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