Chemistry:25B-NB

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25B-NB, also known as N-benzyl-4-bromo-2,5-dimethoxyphenethylamine (N-benzyl-2C-B or NB-2C-B), is a recreational designer drug from the 25-NB subgroup of the substituted phenethylamine family, with psychedelic effects. It has a binding affinity (Ki) of 16 nM at the serotonin receptor 5-HT2A and 90 nM at 5-HT2C and reportedly has a potency in between that of 2C-B and 25B-NBOMe (NBOMe-2C-B).[1][2] 25B-NB was first synthesized and described by Richard Glennon and colleagues in 1994.[2][3][1] It was the first drug of the 25-NB family to be developed.[2][3] Subsequently, modification of 25B-NB led to the development of the more well-known 25-NB family drugs such as 25I-NBOMe.[2][3]

See also

References

  1. ↑ 1.0 1.1 "Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines". Journal of Medicinal Chemistry 37 (13): 1929–1935. June 1994. doi:10.1021/jm00039a004. PMID 8027974. 
  2. ↑ 2.0 2.1 2.2 2.3 "Pharmacology and Toxicology of N-Benzylphenethylamine (“NBOMe”) Hallucinogens". Neuropharmacology of New Psychoactive Substances (NPS).. Current Topics in Behavioral Neurosciences. 32. Cham: Springer. 2017. pp. 283–311. doi:10.1007/7854_2016_64. ISBN 978-3-319-52444-3. 
  3. ↑ 3.0 3.1 3.2 "DARK Classics in Chemical Neuroscience: NBOMes". ACS Chem Neurosci 11 (23): 3860–3869. December 2020. doi:10.1021/acschemneuro.9b00528. PMID 31657895. 


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