Chemistry:2C-Se-TFM

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2C-Se-TFM is a designer drug from the substituted phenethylamine family, which produces psychedelic-like effects in animals such as a head twitch response. It was first synthesised by Josh Hartsel and colleagues in 2024. It has a binding affinity (Ki) of 3.2 nM at the serotonin receptor 5-HT2A and an EC50 of 3.6 nM, acting as a full agonist. Aside from 2C-Se, it is the only psychedelic drug containing a selenium atom, as while other related analogues such as the ethyl compound 2C-Se-2 and the propyl derivative 2C-Se-7 have been proposed as theoretical compounds, neither is known to have been synthesised.[1][2] It is a controlled substance in Canada under phenethylamine blanket-ban language.[3]

See also

References

  1. ↑ "Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT2 Receptor Agonist". Journal of Medicinal Chemistry 67 (8): 6144–6188. April 2024. doi:10.1021/acs.jmedchem.3c01961. PMID 38593423. 
  2. ↑ Nivorozhkin A, Hartsel JA, Canal CE, Salituro FG, Mueller TA, Greene BJ, Belser A, Palfreyman M, "Phenethylamine compounds, compositions, and methods of use.", WO patent 2024/089226, published 2 May 2024
  3. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 




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