Chemistry:2C-T-30

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2C-T-30, also known as 4-(4-fluorobutylthio)-2,5-dimethoxyphenethylamine or as 2C-T-FB, is a serotonin receptor modulator of the phenethylamine and 2C families.[1][2][3] It is the derivative of 2C-T in which the 4-methylthio group has been replaced with a 4-(4-fluorobutylthio) group.[1][2] According to Daniel Trachsel, 2C-T-30 was not clearly active at a dose of 6 mg plus 3 mg orally and its duration and effects are unknown.[2][4] However, it was said that it might have helped increase ability to concentrate on tasks.[2] The drug is a potent partial agonist of the serotonin 5-HT2A receptor and also interacts with other serotonin receptors and targets.[3][1] The chemical synthesis of 2C-T-30 has been described.[5] 2C-T-30 was first described in the scientific literature by Trachsel in 2003.[5] It is a controlled substance in Canada under phenethylamine blanket-ban language.[6]

See also

References

  1. ↑ 1.0 1.1 1.2 (in de) Phenethylamine: von der Struktur zur Funktion. Nachtschatten-Science (1 ed.). Solothurn: Nachtschatten-Verlag. 2013. ISBN 978-3-03788-700-4. OCLC 858805226. https://books.google.com/books?id=-Us1kgEACAAJ. 
  2. ↑ 2.0 2.1 2.2 2.3 "Fluorine in psychedelic phenethylamines". Drug Testing and Analysis 4 (7–8): 577–590. 2012. doi:10.1002/dta.413. PMID 22374819. "Further homologs, 2C-T-19 (41; Ki = 14nM) and 2C-T-30 (42; Ki = 47nM) were tested in radioligand binding assays using [3 H] LSD labelled cloned h5-HT2A receptors, indicating a high affinity of 41 at this binding site. In this case fluorine seemed to decrease affinity slightly by a factor of around three. Virtually nothing is known about their human activities. 2C-T-30 (42) was tested up to 6 + 3 mg which revealed no detectable effects.". 
  3. ↑ 3.0 3.1 "Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)". Neuropharmacology 134 (Pt A): 141–148. May 2018. doi:10.1016/j.neuropharm.2017.07.012. PMID 28720478. 
  4. ↑ "Monoamine Transporter and Receptor Interaction Profiles in Vitro Predict Reported Human Doses of Novel Psychoactive Stimulants and Psychedelics". The International Journal of Neuropsychopharmacology 21 (10): 926–931. October 2018. doi:10.1093/ijnp/pyy047. PMID 29850881. 
  5. ↑ 5.0 5.1 "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur–Aktivitätsbeziehungen. Mitteilung 2: 4-Thio-substituierte [2-(2,5-Dimethoxyphenyl)ethylamine (=2,5-Dimethoxybenzolethanamine)"]. Helvetica Chimica Acta 86 (7): 2610–2619. 2003. doi:10.1002/hlca.200390210. ISSN 0018-019X. https://onlinelibrary.wiley.com/doi/10.1002/hlca.200390210. Retrieved 17 November 2025. 
  6. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 



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