Chemistry:DMCPA

From HandWiki

DMCPA, also known as 2,5-dimethoxy-4-methylphenylcyclopropylamine, is a psychedelic drug of the phenethylamine, amphetamine, and phenylcyclopropylamine families related to DOM.[1] It is a derivative of tranylcypromine and is the cyclized phenethylamine analogue of DOM in which the α and β positions have been connected with a carbon atom to form a cyclopropyl group.[1]

Use and effects

In Alexander Shulgin's book PiHKAL (Phenethylamines I Have Known and Loved), the dose range is listed as 15 to 20 mg and the duration is listed as 4 to 8 hours.[1] DMCPA produces open-eye visuals, anorexia, and psychedelic dreams.[1] One of the reports in PiHKAL gave it a +++ on the Shulgin Rating Scale.[1]

Interactions

Pharmacology

Pharmacodynamics

The comprehensive receptor interactions of DMCPA have been studied.[2]

Chemistry

Synthesis

The chemical synthesis of DMCPA has been described.[1]

History

DMCPA was first described in the scientific literature by at least 1974.[3]

Society and culture

United Kingdom

This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.[4]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 DMCPA Entry in PiHKAL
  2. ↑ "The polypharmacology of psychedelics reveals multiple targets for potential therapeutics". Neuron. July 2025. doi:10.1016/j.neuron.2025.06.012. PMID 40683247. https://www.cell.com/cms/10.1016/j.neuron.2025.06.012/attachment/7d8365fe-51f3-4a28-bf40-9999bec837f6/mmc11.pdf. 
  3. ↑ "Structure-activity relationships in psychotomimetic phenylalkylamines". J Med Chem 17 (10): 1100–1111. October 1974. doi:10.1021/jm00256a016. PMID 4418757. 
  4. ↑ "UK Misuse of Drugs act 2001 Amendment summary". Isomer Design. http://isomerdesign.com/Cdsa/scheduleUK.php?schedule=1&ion=30&structure=C. 



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