Chemistry:Fluoroproscaline

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Fluoroproscaline (FP), also known as 4-(3-fluoropropoxy)-3,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline.[1][2] It is a fluorinated derivative of proscaline.[1][2][3] The drug has a dose range of 60 to 150 mg and a duration of 3 to 5 hours.[1][2] It is less potent than proscaline but more potent than mescaline and is much shorter-acting than proscaline or mescaline.[1][2] The receptor interactions of fluoroproscaline have been studied.[4][1][2] It is a low-affinity and low-potency agonist of the serotonin 5-HT2A receptor.[4][1][2] The chemical synthesis of fluoroproscaline has been described.[3] The drug was first described in the scientific literature by Daniel Trachsel in 2002.[2][1][3] The pharmacology of fluoroproscaline was studied in greater detail in 2021.[4]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 (in de) Phenethylamine: von der Struktur zur Funktion. Nachtschatten-Science (1 ed.). Solothurn: Nachtschatten-Verlag. 2013. pp. 706,712,716–717,736–737. ISBN 978-3-03788-700-4. OCLC 858805226. https://books.google.com/books?id=-Us1kgEACAAJ. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "Fluorine in psychedelic phenethylamines". Drug Testing and Analysis 4 (7–8): 577–590. 2012. doi:10.1002/dta.413. PMID 22374819. "A fluorinated analog of proscaline (79) [3] was also investigated.[86] At the cloned [3 H]ketanserin-labelled serotonin h5-HT2A receptor fluoroproscaline (80: Ki= 8792nM) showed only low affinity and in humans, fluoroproscaline (80: 60–150 mg, 3–5 h) was distinctly less potent and of shorter duration than proscaline (79: 30–60 mg, 8–12 h). Similarly, limited trials suggest that trifluoroproscaline (81: 66 mg or more) might be less potent as well. The preparation of difluoroisoproscaline (82), a fluoro analog of the psychedelic derivative isoproscaline (83),[3] has been achieved.[5]". 
  3. ↑ 3.0 3.1 3.2 "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur-Aktivitätsbeziehungen, Mitteilung 1, Mescalin Derivate.". Helvetica Chimica Acta 85 (9): 3019–3026. 2002. doi:10.1002/1522-2675(200209)85:9<3019::AID-HLCA3019>3.0.CO;2-4. 
  4. ↑ 4.0 4.1 4.2 "Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines". Frontiers in Pharmacology 12. 2021. doi:10.3389/fphar.2021.794254. PMID 35222010. 

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