Chemistry:Trifluoroproscaline

Trifluoroproscaline (TFP), also known as 4-(3,3,3-trifluoropropoxy)-3,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline.^[1]^[2]^[3] It is a trifluorinated derivative of proscaline.^[1]^[2]^[3] Based on limited trials, trifluoroproscaline is active at a dose of 33 to 66 mg or more orally and its duration is unknown.^[1]^[2]^[3] Initial trials provided evidence of effects including good fantasy and slight color intensification.^[1] The drug might be less potent than proscaline similarly to fluoroproscaline.^[2] It acts as a low-potency serotonin 5-HT_2A receptor partial agonist and also interacts with other serotonin receptors and targets.^[3] Trifluoroproscaline was first described in the scientific literature by Daniel Trachsel in 2012.^[1]^[3]^[2] Its pharmacology was subsequently studied in greater detail in 2021.^[3] It is not a controlled substance in Canada as of 2025.^[4]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 (in de) Phenethylamine: von der Struktur zur Funktion. Nachtschatten-Science (1 ed.). Solothurn: Nachtschatten-Verlag. 2013. pp. 706,712. ISBN 978-3-03788-700-4. OCLC 858805226. https://books.google.com/books?id=-Us1kgEACAAJ.
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 "Fluorine in psychedelic phenethylamines". Drug Testing and Analysis 4 (7–8): 577–590. 2012. doi:10.1002/dta.413. PMID 22374819. "A fluorinated analog of proscaline (79) [3] was also investigated.[86] At the cloned [3 H]ketanserin-labelled serotonin h5-HT2A receptor fluoroproscaline (80: Ki= 8792nM) showed only low affinity and in humans, fluoroproscaline (80: 60–150 mg, 3–5 h) was distinctly less potent and of shorter duration than proscaline (79: 30–60 mg, 8–12 h). Similarly, limited trials suggest that trifluoroproscaline (81: 66 mg or more) might be less potent as well.".
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 "Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines". Frontiers in Pharmacology 12. 2021. doi:10.3389/fphar.2021.794254. PMID 35222010.
↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html.

External links

3,3,3-Trifluoroproscaline (3,3,3-TFP) - Isomer Design

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[Trachsel_2013-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 (in de) Phenethylamine: von der Struktur zur Funktion. Nachtschatten-Science (1 ed.). Solothurn: Nachtschatten-Verlag. 2013. pp. 706,712. ISBN 978-3-03788-700-4. OCLC 858805226. https://books.google.com/books?id=-Us1kgEACAAJ.

[Trachsel_2012-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 "Fluorine in psychedelic phenethylamines". Drug Testing and Analysis 4 (7–8): 577–590. 2012. doi:10.1002/dta.413. PMID 22374819. "A fluorinated analog of proscaline (79) [3] was also investigated.[86] At the cloned [3 H]ketanserin-labelled serotonin h5-HT2A receptor fluoroproscaline (80: Ki= 8792nM) showed only low affinity and in humans, fluoroproscaline (80: 60–150 mg, 3–5 h) was distinctly less potent and of shorter duration than proscaline (79: 30–60 mg, 8–12 h). Similarly, limited trials suggest that trifluoroproscaline (81: 66 mg or more) might be less potent as well.".

[Kolaczynska_2021-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 "Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines". Frontiers in Pharmacology 12. 2021. doi:10.3389/fphar.2021.794254. PMID 35222010.

[CDSA-4] "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html.

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