Chemistry:2,4,6-TMPEA-NBOMe

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2,4,6-TMPEA-NBOMe, also known as ψ-2C-O-NBOMe or 26O-NBOMe as well as N-(2-methoxybenzyl)-2,4,6-trimethoxyphenethylamine, is a psychedelic drug of the phenethylamine, ψ-PEA, and N-benzylphenethylamine (NBOMe) families.[1][2][3][4][5] It is the NBOMe derivative of ψ-2C-O (2,4,6-TMPEA).[5] The drug is said to produce psychedelic effects such as visuals.[1][2] It has been found to act as a potent serotonin 5-HT2A receptor partial agonist, with an EC50 of 1.7 nM and an Emax of 49%.[3][4] 2,4,6-TMPEA-NBOMe was first described in the scientific literature in 2009.[3][4] Subsequently, it was encountered as a novel designer drug in Russia in 2015.[5][1][2] The drug is a controlled substance in Canada under phenethylamine blanket-ban language.[6]

See also

References

  1. ↑ 1.0 1.1 1.2 "2,4,6-TMPEA-NBOMe" (in ru). https://aipsin.com/newsubstance/1144/. 
  2. ↑ 2.0 2.1 2.2 "2,4,6-TMPEA-NBOMe." (in ru). https://aipsin.com/newsubstance/1276/. 
  3. ↑ 3.0 3.1 3.2 Silva M (2009). Theoretical study of the interaction of agonists with the 5-HT2A receptor (Ph.D.). Universität Regensburg. Table 5.1: Agonistic potency (pEC50) and intrinsic activity (Emax) of 5-HT2AR partial agonistic arylethylamines (indole, methoxybenzene and quinazolinedione derivatives) used in the study. [...]
  4. ↑ 4.0 4.1 4.2 "Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor". Journal of Computer-Aided Molecular Design 25 (1): 51–66. January 2011. doi:10.1007/s10822-010-9400-2. PMID 21088982. 
  5. ↑ 5.0 5.1 5.2 "Mass spectrometric properties of N-(2-methoxybenzyl)-2-(2,4,6-trimethoxyphenyl)ethanamine (2,4,6-TMPEA-NBOMe), a new representative of designer drugs of NBOMe series and derivatives thereof". Journal of Mass Spectrometry 51 (10): 969–979. October 2016. doi:10.1002/jms.3808. PMID 27388323. Bibcode: 2016JMSp...51..969S. 
  6. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 



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