Chemistry:2-Iodomescaline

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2-Iodomescaline (2-I-M), also known as 2-iodo-3,4,5-trimethoxyphenethylamine, is a serotonin receptor modulator of the phenethylamine and scaline families related to mescaline.[1] It is the 2-iodo derivative of mescaline.[1] The drug shows affinity for the serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors (Ki = 190 nM, 376 nM, and 240 nM, respectively).[1] These affinities were 16-fold, 12-fold, and 32-fold higher than those of mescaline, respectively.[1] The drug is not known to have been tested in animals or humans.[1] The chemical synthesis of 2-iodomescaline has been described.[2] 2-Iodomescaline was first described in the scientific literature by Jose A. Sintas and colleagues by 1998.[2] Subsequently, it was described in greater detail by Daniel Trachsel and colleagues in 2013.[1] The source of the information cited by Trachsel and colleagues was personal communication with David E. Nichols in 2010.[1] It is not a controlled substance in Canada as of 2025.[3]

See also

  • Scaline
  • 2-Bromomescaline
  • 2-Chloromescaline
  • 2-Methylmescaline
  • TeMPEA (2-methoxymescaline)

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 (in de) Phenethylamine: von der Struktur zur Funktion. Nachtschatten-Science (1 ed.). Solothurn: Nachtschatten-Verlag. 2013. pp. 908–909. ISBN 978-3-03788-700-4. OCLC 858805226. https://books.google.com/books?id=-Us1kgEACAAJ. 
  2. ↑ 2.0 2.1 "Synthesis of derivatives of [I-131 phenylalkylamines for brain mapping"]. Journal of Labelled Compounds and Radiopharmaceuticals 41 (1): 53–61. 1998. doi:10.1002/(SICI)1099-1344(199801)41:1<53::AID-JLCR53>3.0.CO;2-K. https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1099-1344(199801)41:13.0.CO;2-K. Retrieved 26 November 2025. 
  3. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 



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