Chemistry:Clausenamide

Clausenamide is an alkaloid found in Clausena lansium (wampee), an evergreen tree native to Southeast Asia and southern China.^[1]^[2] The compound has multiple chiral centers and many possible enantiomers or stereoisomers.^[1]^[2] Some of its isomers, especially (–)-cis-clausenamide, show psychoplastogenic effects that may be due to serotonin 5-HT_2A receptor partial agonism.^[2] In a BRET assay, (–)-cis-clausenamide showed modest potency and efficacy as a serotonin 5-HT_2A receptor partial agonist (EC₅₀ = 490 nM; E_max = 28.4%).^[2] A number of other biological activities of clausenamide have also been described, and the compound has potential medical applications.^[1]^[3] Clausenamide was first isolated and described in the scientific literature by 1987.^[4] The psychoplastogenic activity of clausenamide was described by David E. Olson and colleagues in 2026.^[2]

References

↑ ^1.0 ^1.1 ^1.2 "Recent advances in the study of (-)clausenamide: chemistry, biological activities and mechanism of action". Acta Pharmaceutica Sinica. B 4 (6): 417–423. December 2014. doi:10.1016/j.apsb.2014.10.004. PMID 26579412.
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 "Synthesis of Clausenamide Isomers and Evaluation of Their Potential as Cortical Neuroplastogens". ACS Chemical Neuroscience. May 2026. doi:10.1021/acschemneuro.5c00767. PMID 42089448.
↑ "The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect". Pharmacology & Therapeutics 162: 179–187. June 2016. doi:10.1016/j.pharmthera.2016.01.002. PMID 26812265.
↑ "[Isolation and structural elucidation of clausenamide from the leaves of Clausena lansium (Lour.) Skeels]" (in Chinese). Yao Xue Xue Bao = Acta Pharmaceutica Sinica 22 (1): 33–40. January 1987. PMID 3604690.

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[ChuZhang2014-1] 1.0 ^1.1 ^1.2 "Recent advances in the study of (-)clausenamide: chemistry, biological activities and mechanism of action". Acta Pharmaceutica Sinica. B 4 (6): 417–423. December 2014. doi:10.1016/j.apsb.2014.10.004. PMID 26579412.

[OuKhatibMosswood2026-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 "Synthesis of Clausenamide Isomers and Evaluation of Their Potential as Cortical Neuroplastogens". ACS Chemical Neuroscience. May 2026. doi:10.1021/acschemneuro.5c00767. PMID 42089448.

[ChuLiuDuan2016-3] "The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect". Pharmacology & Therapeutics 162: 179–187. June 2016. doi:10.1016/j.pharmthera.2016.01.002. PMID 26812265.

[YangCaoLi1987-4] "[Isolation and structural elucidation of clausenamide from the leaves of Clausena lansium (Lour.) Skeels]" (in Chinese). Yao Xue Xue Bao = Acta Pharmaceutica Sinica 22 (1): 33–40. January 1987. PMID 3604690.

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