Chemistry:2CB-2OCD3

2CB-2OCD₃
Clinical data
Other names	2C-B-2-OCD3; 2-Trideuteromethoxy-2C-B; 4-Bromo-2-trideuteromethoxy-5-methoxyphenethylamine; 2-(4-Bromo-5-methoxy-2-(methoxy-d3)phenyl)ethan-1-amine
Drug class	Serotonin 5-HT2A receptor agonist; Possible serotonergic psychedelic or hallucinogen
ATC code	None;
Identifiers
	IUPAC name 2-[4-bromo-5-methoxy-2-(trideuteriomethoxy)phenyl]ethanamine;
PubChem CID	167477086;
Chemical and physical data
Formula	C10H14BrNO2
Molar mass	260.131 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [2H]C([2H])([2H])OC1=CC(=C(C=C1CCN)OC)Br;
	InChI InChI=1S/C10H14BrNO2/c1-13-9-6-8(11)10(14-2)5-7(9)3-4-12/h5-6H,3-4,12H2,1-2H3/i1D3; Key:YMHOBZXQZVXHBM-FIBGUPNXSA-N;

2CB-2OCD₃, also known as 2-trideuteromethoxy-2C-B, is a serotonin 5-HT_2A receptor agonist and possible psychedelic drug of the phenethylamine and 2C families.^[1]^[2] It is the isotopologue of 2C-B in which the three hydrogen atoms of the methoxy group at the 2 position have been replaced with the deuterium isotopes.^[1]^[2] The drug shows similar serotonin 5-HT_2A receptor pharmacodynamics and metabolism as 2C-B in vitro.^[1]^[2] The chemical synthesis of 2CB-2OCD₃ has been described.^[1]^[2] 2CB-2OCD₃ was developed by Nicholas V. Cozzi and Paul F. Daley of the Alexander Shulgin Research Institute (ASRI).^[1]^[2] It was patented in 2024^[2] and was first described in the scientific literature in 2026.^[1]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 "Serotonin 2A receptor binding, functional activity, and in vitro metabolism of two trideuteromethoxy 2C-B isotopologues". Naunyn-Schmiedeberg's Archives of Pharmacology. June 2026. doi:10.1007/s00210-026-05566-5. PMID 42313138.
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Daley PF, Cozzi NV, "Substituted phenylalkylamines", US patent 20240408038, published 2024-12-12, issued 2025-11-11, assigned to Alexander Shulgin Research Institute Inc

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[Cozzi2026-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 "Serotonin 2A receptor binding, functional activity, and in vitro metabolism of two trideuteromethoxy 2C-B isotopologues". Naunyn-Schmiedeberg's Archives of Pharmacology. June 2026. doi:10.1007/s00210-026-05566-5. PMID 42313138.

[DaleyCozzi2024-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Daley PF, Cozzi NV, "Substituted phenylalkylamines", US patent 20240408038, published 2024-12-12, issued 2025-11-11, assigned to Alexander Shulgin Research Institute Inc

[1]

[2]

v t e Phenethylamines
Phenethylamines	Psychedelics: 25B-NBOMe 25C-NBOMe 25D-NBOMe 25I-NBOMe 25N-NBOMe 2C-B 2C-B-AN 2C-Bn 2C-Bu 2C-C 2C-CN 2C-CP 2C-D 2C-E 2C-EF 2C-F 2C-G 2C-G-1 2C-G-2 2C-G-3 2C-G-4 2C-G-5 2C-G-6 2C-G-N 2C-H 2C-I 2C-iP 2C-N 2C-NH2 2C-O 2C-O-4 2C-P 2C-Ph 2C-SE 2C-T 2C-T-2 2C-T-3 2C-T-4 2C-T-5 2C-T-6 2C-T-7 2C-T-8 2C-T-9 2C-T-10 2C-T-11 2C-T-12 2C-T-13 2C-T-14 2C-T-15 2C-T-16 2C-T-17 2C-T-18 2C-T-19 2C-T-20 2C-T-21 2C-T-22 2C-T-22.5 2C-T-23 2C-T-24 2C-T-25 2C-T-27 2C-T-28 2C-T-30 2C-T-31 2C-T-32 2C-T-33 2C-TFE 2C-TFM 2C-YN 2C-V Allylescaline DESOXY Escaline Isoproscaline Jimscaline Macromerine MEPEA Mescaline Metaescaline Methallylescaline Proscaline Psi-2C-T-4 TCB-2 Stimulants: Phenylethanolamine Hordenine Phenethylamine α-Methylphenethylamine (amphetamine) β-Methylphenethylamine m-Methylphenethylamine N-Methylphenethylamine o-Methylphenethylamine p-Methylphenethylamine Methylphenidate Entactogens: Lophophine MDPEA MDMPEA Others: BOH DMPEA
Amphetamines	Psychedelics: 3C-BZ 3C-E 3C-P Aleph Beatrice Bromo-DragonFLY D-Deprenyl DMA DMCPA DMMDA DOB DOC DOEF DOET DOI DOM DON DOPR DOTFM Ganesha MMDA MMDA-2 Psi-DOM TMA TeMA Stimulants: 2-FA 2-FMA 3-FA 3-FMA Acridorex Alfetamine Amfecloral Amfepentorex Amphetamine (Dextroamphetamine, Levoamphetamine) Amphetaminil Benfluorex Benzphetamine Cathine Clobenzorex Dimethylamphetamine Ephedrine Etilamfetamine Fencamfamin Fencamine Fenethylline Fenfluramine (Dexfenfluramine, Levofenfluramine) Fenproporex Flucetorex Fludorex Formetorex Furfenorex Gepefrine 4-Hydroxyamphetamine Iofetamine Isopropylamphetamine Lefetamine Lisdexamfetamine Mefenorex Metaraminol Methamphetamine (Dextromethamphetamine, Levomethamphetamine) Methoxyphenamine MMA Morforex Norfenfluramine L -Norpseudoephedrine N,alpha-Diethylphenylethylamine Oxifentorex Oxilofrine Ortetamine PBA PCA Phenpromethamine PFA PFMA PIA PMA PMEA PMMA Phenylpropanolamine Pholedrine Prenylamine Propylamphetamine Pseudoephedrine Sibutramine Tiflorex Tranylcypromine Xylopropamine Zylofuramine Entactogens: 4-FA 4-FMA 4-MA 4-MMA 4-MTA 5-APB 5-APDB 5-EAPB 5-IT 5-MAPB 5-MAPDB 6-APB 6-APDB 6-Chloro-MDMA 6-EAPB 6-IT 6-MAPB 6-MAPDB EDA IAP 2,3-MDA 3,4-MDA (tenamfetamine) MDEA MDHMA MDMA (midomafetamine) MDOH Methamnetamine MMDMA Naphthylaminopropane TAP Others: 3,4-DCA Amiflamine DiFMDA Selegiline (also D -Deprenyl)
Phentermines	Stimulants: Chlorphentermine Cloforex Clortermine Etolorex Mephentermine Pentorex Phentermine Entactogens: MDPH MDMPH Others: Cericlamine
Cathinones	Stimulants: 3-FMC 4-MC 4-BMC 4-CMC 4-EMC 4-FMC 4-MEC 4-MeMABP 4-MPD Amfepramone Benzedrone Brephedrone Buphedrone Bupropion Cathinone Dimethylcathinone Ethcathinone Eutylone Hydroxybupropion Methcathinone Methedrone NEB N-Ethylhexedrone N-Ethylpentedrone Pentedrone Pentylone Radafaxine Entactogens: 3,4-DMMC 3-MMC Butylone Ethylone Methylone Methylenedioxycathinone Mephedrone
Phenylisobutylamines	Entactogens: 4-CAB 4-MAB Ariadne BDB Butylone EBDB Eutylone MBDB Stimulants: Phenylisobutylamine
Phenylalkylpyrrolidines	Stimulants: α-PBP α-PHP α-PPP α-PVP MDPBP MDPPP MDPV 4-MePBP 4-MePHP 4-MePPP MOPPP MOPVP MPBP MPHP MPPP Naphyrone PEP Prolintane Pyrovalerone
Catecholamines (and close relatives)	6-FNE 6-OHDA a-Me-DA a-Me-TRA Adrenochrome Ciladopa D -DOPA (Dextrodopa) Dimetofrine Dopamine Epinephrine Epinine Etilefrine Ethylnorepinephrine Fenclonine Ibopamine Isoprenaline Isoetarine L -DOPA (Levodopa) L -DOPS (Droxidopa) L -Phenylalanine L -Tyrosine m-Tyramine Metanephrine Metaraminol Metaterol Metirosine Methyldopa N,N-Dimethyldopamine Nordefrin (Levonordefrin) Norepinephrine Norfenefrine (m-Octopamine) Normetanephrine Orciprenaline p-Octopamine p-Tyramine Phenylephrine Synephrine
Miscellaneous	AL-LAD Amidephrine Arbutamine Cafedrine Denopamine Desvenlafaxine Diphenidine Dizocilpine Dobutamine Dopexamine Ephenidine Etafedrine ETH-LAD Famprofazone Fluorolintane Hexapradol IP-LAD Lysergic acid amide Lysergic acid 2-butyl amide Lysergic acid 2,4-dimethylazetidide Lysergic acid diethylamide Methoxamine Methoxphenidine MT-45 PARGY-LAD Phenibut PRO-LAD Pronethalol Salbutamol (Levosalbutamol) Solriamfetol Theodrenaline Thiamphenicol UWA-101

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Other names	2C-B-2-OCD₃; 2-Trideuteromethoxy-2C-B; 4-Bromo-2-trideuteromethoxy-5-methoxyphenethylamine; 2-(4-Bromo-5-methoxy-2-(methoxy-d3)phenyl)ethan-1-amine
Drug class	Serotonin 5-HT_2A receptor agonist; Possible serotonergic psychedelic or hallucinogen
ATC code	None
Identifiers
IUPAC name 2-[4-bromo-5-methoxy-2-(trideuteriomethoxy)phenyl]ethanamine
PubChem CID	167477086
Chemical and physical data
Formula	C₁₀H₁₄BrNO₂
Molar mass	260.131 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES [2H]C([2H])([2H])OC1=CC(=C(C=C1CCN)OC)Br
InChI InChI=1S/C10H14BrNO2/c1-13-9-6-8(11)10(14-2)5-7(9)3-4-12/h5-6H,3-4,12H2,1-2H3/i1D3 Key:YMHOBZXQZVXHBM-FIBGUPNXSA-N

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