Chemistry:B-193

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B-193 is a serotonin 5-HT2 receptor antagonist of the β-carboline family.[1][2] It shows affinity for serotonin 5-HT2 and α1-adrenergic receptors and much lower affinity for serotonin 5-HT1 and α2-adrenergic receptors.[1] The drug also inhibits serotonin-induced contractions in the rat fundus stomach strip.[1] Conversely, it does not inhibit serotonin or norepinephrine reuptake.[2]

B-193 reverses the effects of various serotonergic agents in animals, such as the head-twitch response induced by 5-HTP and LSD and the hyperthermia induced by fenfluramine and mCPP, among various others.[1] On the other hand, it does not influence effects of most dopaminergic agents, including reserpine, levodopa, and apomorphine, though it did enhance amphetamine-induced hyperlocomotion.[2] The drug produces antidepressant-like effects in rodents and was regarded as having the profile of an atypical antidepressant.[2] The toxicity of B-193 has been studied.[3][4]

B-193 was first described in the scientific literature by 1989.[1][2]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 "Antiserotonin activity of 9-methyl-2-[3-(4-phenyl-1-piperazinylpropyl)]-1,2,3,4-tetrahydro -beta-carbolin-1-one (B-193)". Polish Journal of Pharmacology and Pharmacy 41 (2): 169–181. 1989. PMID 2556691. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 "Antidepressant profile of 9-methyl-2[-3-(4-phenyl-1-piperazinylpropyl)]-1,2,3,4-tetrahydro-beta- carbolin-1-one (B-193)". Polish Journal of Pharmacology and Pharmacy 41 (4): 331–344. 1989. PMID 2636891. 
  3. ↑ "Some pharmacological properties and cumulative, subchronic and chronic toxicity of 9-methyl-2-[3-(4-phenyl-1-piperazinylpropyl)] -1,2,3,4-tetrahydro-beta-carbolin-1-one (B-193)". Polish Journal of Pharmacology 47 (4): 305–311. 1995. PMID 8616509. 
  4. ↑ "Embryotoxic effects of B-193 in mouse". Folia Morphologica 55 (4): 200–201. 1996. PMID 9243847. 



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