Chemistry:Dihydrokavain
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| Names | |
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| IUPAC name
4-Methoxy-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-one
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| Other names
Dihydrokawain
Marindinin | |
| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C14H16O3 | |
| Molar mass | 232.27 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
Tracking categories (test):
Dihydrokavain is one of the six major kavalactones found in the kava plant.[1] It appears to contribute significantly to the anxiolytic effects of kava, based on a study in chicks.[2]
Dihydrokavain bears some structural similarity to the strobilurins and has some fungicidal activity.[3]
An analogue of the molecule was also shown to improve glycemic control by modulating AMPK target genes expression in fruit flies.[4]
References
- ↑ Malani, Joji (2002-12-03). "Evaluation of the effects of Kava on the Liver". Fiji School of Medicine. http://www.spc.int/cis/documents/Kava%20article%20DrMalani.pdf. Retrieved 2009-09-04.
- ↑ Feltenstein, MW; LC Lambdin; M Ganzera; H Ranjith; W Dharmaratne; NP Nanayakkara; IA Khan; KJ Sufka (March 2003). "Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure.". Phytotherapy Research 17 (3): 210–216. doi:10.1002/ptr.1107. PMID 12672148.
- ↑ Zakharychev, Vladimir V; Kovalenko, Leonid V (1998-06-30). "Natural compounds of the strobilurin series and their synthetic analogues as cell respiration inhibitors". Russian Chemical Reviews 67 (6): 535–544. doi:10.1070/rc1998v067n06abeh000426. ISSN 0036-021X. Bibcode: 1998RuCRv..67..535Z.
- ↑ Hadiza Muhammad Maiturare; Mudassir Aliyu Magaji; Muhammad Kabiru Dallatu; Kabir Magaji Hamid; Mustapha Umar Imam; Ibrahim Malami (2022). "5,6-dehydrokawain improves glycaemic control by modulating AMPK target genes in Drosophila with a high-sucrose diet-induced hyperglycaemia" (in English). Phytomedicine Plus 2 (2): 100261–. doi:10.1016/j.phyplu.2022.100261. ISSN 2667-0313. https://pubag.nal.usda.gov/catalog/7719064.
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