Chemistry:BGC20-761

From HandWiki

BGC20-761 (5-MeO-2-phenyl-DMT, PMDT) is an experimental drug which acts as an antagonist of the 5-HT6, 5-HT2 family, and dopamine D2 receptors, with strongest affinity for 5-HT6. In animal studies it has antipsychotic-like effects, but also memory enhancing action attributed to its 5-HT6 affinity.[1][2][3]

See also

References

  1. ↑ "BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism". Neuropharmacology 50 (4): 412–420. March 2006. doi:10.1016/j.neuropharm.2005.10.002. PMID 16298400. 
  2. ↑ "E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat". Psychopharmacology 213 (2–3): 413–430. February 2011. doi:10.1007/s00213-010-1854-3. PMID 20405281. 
  3. ↑ "Role of serotonin in Alzheimer's disease: a new therapeutic target?". CNS Drugs 25 (9): 765–781. September 2011. doi:10.2165/11590190-000000000-00000. PMID 21870888. 



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