Chemistry:NBoc-DMT

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NBoc-DMT, or NB-DMT, also known as N1-tert-butoxycarbonyl-N,N-dimethyltryptamine, is a serotonergic psychedelic of the tryptamine family.[1][2] It is a novel designer and recreational drug and is a synthetic modification of dimethyltryptamine (DMT) with an N′-tert-butyloxycarbonyl (NBoc) group.[1][2]

NB-DMT is said to be a "prodrug" of DMT that decomposes into DMT when the compound is heated (e.g., with smoking or vaping).[1] It may also be useful as an orally active prodrug of DMT, unlike DMT itself which is inactive when taken orally.[3][4] NB-DMT has been claimed to have about 25% of the potency of DMT by weight.[1]

It was first detected as a designer drug being sold online by February 2024.[1] NB-DMT is a Schedule I controlled substance in Russia.[1] A number of other NBoc designer drugs have also been encountered.[1][5]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "DMT BOC (NB-DMT)" (in ru). https://aipsin.com/newsubstance/1361/. 
  2. ↑ 2.0 2.1 "Tert-butyl 3-[2-(dimethylamino)ethylindole-1-carboxylate"]. PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/141803940. 
  3. ↑ Alexander M, Duncton J, Clark S, "N,N-dimethyltryptamine and related psychedelics and uses thereof.", US patent 2024/0116870, published 11 April 2024
  4. ↑ Buchner M, "Novel N,N-Dimethyltryptamine (DMT) derivatives and uses thereof.", WO patent 2024/121253, published 13 June 2024
  5. ↑ "Chemical camouflage: illicit drug concealment using di-tert-butyldicarbonate". Australian Journal of Forensic Sciences 51: S217–S219. 2019. doi:10.1080/00450618.2019.1569135. 


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