Chemistry:Pyr-AI

From HandWiki

Pyr-AI, also known as 2-pyrrolidinylindane (2-PYI), is a stimulant drug of the 2-aminoindane family.[1] It is the analogue of 2-aminoindane (2-AI) in which the amine has been replaced with a pyrrolidine group.[1] The drug has been described as having strong and long-lasting amphetamine-like effects in rodents.[1][2] Other 2-aminoindanes like 2-AI itself and NM-2-AI are known to act as potent monoamine releasing agents and reuptake inhibitors.[3][4] Pyr-AI was first described in the scientific literature by 1973.[1][2]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 "Aminoindane Analogues". Novel Psychoactive Substances. Elsevier. 2013. pp. 261–283. doi:10.1016/b978-0-12-415816-0.00011-0. ISBN 978-0-12-415816-0. https://linkinghub.elsevier.com/retrieve/pii/B9780124158160000110. Retrieved 2 November 2025. "A ‘strong amphetamine-type activity’ has been reported for the pyrrolidine derivative of 2-AI (26, Fig. 11.10) [41] and ‘a long duration’ of activity was observed at the 10mg/kg dose in mice. Details about the procedure were not provided but neuropharmacological screenings were based on observational methods [48]. A piperidine derivative (27, PIP-AI), on the other hand, showed analgesic properties comparable to meperidine [41]." 
  2. ↑ 2.0 2.1 "2-Aminoindans of pharmacological interest". Journal of Medicinal Chemistry 16 (12): 1330–1333. December 1973. doi:10.1021/jm00270a004. PMID 4765859. 
  3. ↑ "Designer drugs: mechanism of action and adverse effects". Archives of Toxicology 94 (4): 1085–1133. April 2020. doi:10.1007/s00204-020-02693-7. PMID 32249347. Bibcode: 2020ArTox..94.1085L. 
  4. ↑ "2-Aminoindan and its ring-substituted derivatives interact with plasma membrane monoamine transporters and α2-adrenergic receptors". Psychopharmacology 236 (3): 989–999. March 2019. doi:10.1007/s00213-019-05207-1. PMID 30904940. 



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