Chemistry:3-Chloromethcathinone
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Short description: Stimulant designer drug
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| Formula | C10H12ClNO |
| Molar mass | 197.66 g·mol−1 |
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3-Chloromethcathinone (also known as 3-CMC and clophedrone) is a stimulant drug of the cathinone class that has been sold online as a designer drug mainly in European countries such as Ireland, Italy, Poland and Sweden.[1][2][3]
The pharmacology of 3-CMC is unknown, though it is probably a dopamine and serotonin releasing agent. Its chemical structure bears some resemblance to bupropion, but more closely resembles para-chloromethamphetamine which is neurotoxic. Studies in mice indicate 3-CMC is neurotoxic[4]
Legality
As of October 2015 3-CMC is a controlled substance in China.[5] As of April 2019 it is classified as a dangerous and prohibited drug in Sweden.[6] As of March 2023 3-CMC is a controlled substance in Romania.[7]
See also
- 3-Fluoromethcathinone
- 3-Fluoromethamphetamine
- 3-Methylmethcathinone
- 3-Chloromethamphetamine
- 4-Chloromethcathinone
- 5-Cl-bk-MPA
- Substituted cathinone
References
- ↑ "A snapshot on NPS in Italy: Distribution of drugs in seized materials analysed in an Italian forensic laboratory in the period 2013-2015". Forensic Science International 265: 116–20. August 2016. doi:10.1016/j.forsciint.2016.01.037. PMID 26874736.
- ↑ "Identification and structural characterization of synthetic cathinones: N-propylcathinone, 2,4-dimethylmethcathinone, 2,4-dimethylethcathinone, 2,4-dimethyl-α-pyrrolidinopropiophenone, 4-bromo-α-pyrrolidinopropiophenone, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one and 2,4-dimethylisocathinone.". Forensic Toxicol 37 (2): 288–307. February 2019. doi:10.1007/s11419-018-00463-w.
- ↑ Killeen, N., McNamara, S., Stokes, S, & Keenan, E (2022). "Safer Nightlife Programme 2022: Results from ‘back of house’ drug testing", National Social Inclusion Office, Health Service Executive [HSE] of Ireland. ISBN 978-1-898098-08-9
- ↑ Wojcieszak, Jakub & Kuczyńska, Katarzyna & Zawilska, Jolanta. (2020). Four Synthetic Cathinones: 3-Chloromethcathinone, 4-Chloromethcathinone, 4-Fluoro-α-Pyrrolidinopentiophenone, and 4-Methoxy-α-Pyrrolidinopentiophenone Produce Changes in the Spontaneous Locomotor Activity and Motor Performance in Mice with Varied Profiles. Neurotoxicity Research. 38. 10.1007/s12640-020-00227-8
- ↑ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in zh). China Food and Drug Administration. 27 September 2015. http://www.sfda.gov.cn/WS01/CL0056/130753.html.
- ↑ Åtta nya ämnen klassas som narkotika, 5 April 2019[|permanent dead link|dead link}}]
- ↑ ProLege, Redacția (2023-03-03). "Legea nr. 143/2000 privind prevenirea şi combaterea traficului şi consumului ilicit de droguri. Legea nr. 194/2011 privind combaterea operaţiunilor cu produse susceptibile de a avea efecte psihoactive – modificări (Legea nr. 45/2023)" (in ro-RO). https://www.universuljuridic.ro/legea-nr-143-2000-privind-prevenirea-si-combaterea-traficului-si-consumului-ilicit-de-droguri-legea-nr-194-2011-privind-combaterea-operatiunilor-cu-produse-susceptibile-de-a-avea-efecte-psihoactive/.
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