Chemistry:UCD0830

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UCD0830, also known as N,N-dimethyl-2-aminotetralin (N,N-DiMe-2-AT), is a serotonin receptor modulator of the 2-aminotetralin family.[1][2][3] It is the N,N-dimethyl derivative of 2-aminotetralin (2-AT) and is a cyclized phenethylamine as well as a partial ergoline.[1][2][3]

Pharmacology

UCD0830 is a potent partial agonist of the serotonin 5-HT2C receptor, with an EC50 of 167 nM and an Emax of 52%.[1] It is selective for activation of this receptor over the serotonin 5-HT2A and 5-HT2B receptors, where it shows no significant agonism at concentrations of up to 10,000 nM.[1] However, UCD0830 shows weak but detectable affinity for the serotonin 5-HT2A receptor (Ki = 2,290 nM).[1] In accordance with its lack of serotonin 5-HT2A receptor agonism, UCD0830 did not produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.[1] Other behavioral effects in animals have also been described.[3]

Chemistry

The chemical synthesis of UCD0830 has been described.[1]

History

UCD0830 was first described in the scientific literature by 1980.[2][3] Subsequently, it was studied and described in greater detail by David E. Olson and colleagues at the University of California, Davis in 2026.[1]

See also

  • Substituted 2-aminotetralin
  • Cyclized phenethylamine
  • Partial ergoline
  • MDMAT

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 "Deconstruction of lysergic acid diethylamide". Proceedings of the National Academy of Sciences of the United States of America 123 (38). September 2026. doi:10.1073/pnas.2603412123. PMID 42709856. 
  2. ↑ 2.0 2.1 2.2 (in de) Phenethylamine: von der Struktur zur Funktion. Nachtschatten-Science (1 ed.). Solothurn: Nachtschatten-Verlag. 2013. ISBN 978-3-03788-700-4. OCLC 858805226. https://books.google.com/books?id=-Us1kgEACAAJ. 
  3. ↑ 3.0 3.1 3.2 3.3 "Comparison of biological effects of N-alkylated congeners of beta-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene". Journal of Medicinal Chemistry 23 (7): 745–749. July 1980. doi:10.1021/jm00181a009. PMID 7190613. 



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