Chemistry:Α-Methylmethcathinone

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α-Methylmethcathinone (α-Me-MC), also known as βk-mephentermine or as RAD-081, is a norepinephrine–dopamine releasing agent (NDRA) of the amphetamine, cathinone, and phentermine families.[1][2][3] It is the α-methyl analogue of methcathinone and the β-keto analogue of mephentermine.[1][2][3] The drug's EC50 values for induction of monoamine release are 153 nM for norepinephrine, 590 nM for dopamine, and 12,860 nM for serotonin in rat brain synaptosomes.[1][2][3] α-Methylmethcathinone was first described in the scientific literature by 2019.[1][2][3]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 "Investigation of the Optical Isomers of Methcathinone, and Two Achiral Analogs, at Monoamine Transporters and in Intracranial Self-Stimulation Studies in Rats". ACS Chemical Neuroscience 11 (12): 1762–1769. June 2020. doi:10.1021/acschemneuro.9b00617. PMID 32356961. 
  2. ↑ 2.0 2.1 2.2 2.3 Nguyen V (2019). Analyzing Interactions Between Methcathinone Analogs and the Human Monoamine Transporters. Theses and Dissertations (Master of Science thesis). Virginia Commonwealth University. doi:10.25772/T1DW-MG60 – via VCU Scholars Compass.
  3. ↑ 3.0 3.1 3.2 3.3 Davies RA (10 July 2019). Structure-Activity Relationship Studies of Synthetic Cathinones and Related Agents. Theses and Dissertations (Doctor of Philosophy thesis). Virginia Commonwealth University. doi:10.25772/TZSA-0396. Retrieved 24 November 2024 – via VCU Scholars Compass.