Chemistry:Testosterone undecanoate

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Short description: Chemical compound
Testosterone undecanoate
Testosterone undecanoate.svg
Testosterone undecanoate molecule ball.png
Clinical data
Pronunciation/tɛˈstɒstəroʊn ənˈdɛkənoʊeɪt/ teh-STOS-tə-rohn ən-DEK-ə-noh-ayt
Trade namesOral: Kyzatrex, Andriol, Jatenzo, others
IM: Aveed, Nebido, others
Other namesTU; Testosterone undecylate; Testosterone 17β-undecanoate; ORG-538; CLR-610
AHFS/Drugs.comMonograph
MedlinePlusa614041
License data
Pregnancy
category
Routes of
administration		By mouth, intramuscular injection
Drug classAndrogen; Anabolic steroid; Androgen ester
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityOral: 3–7%
Intramuscular: high
Protein bindingHigh (testosterone)
MetabolismLiver
MetabolitesTestosterone, undecanoic acid, metabolites of testosterone
Elimination half-lifeIM (in tea seed oil): 20.9 days[5][6]
IM (in castor oil): 33.9 days[5][6]
Excretion~90% Urine, 6% feces
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC30H48O3
Molar mass456.711 g·mol−1
3D model (JSmol)
  (verify)

Testosterone undecanoate, sold under the brand names Andriol, Aveed and Nebido among others, is an androgen and anabolic steroid (AAS) medication that is used mainly in the treatment of low testosterone levels in men,[7][5][8][9][10][11][12] It is taken by mouth or given by injection into muscle.[9][13]

Side effects of testosterone undecanoate include symptoms of masculinization like acne, increased hair growth, voice changes, hypertension, elevated liver enzymes, hypertriglyceridemia, and increased sexual desire.[9] The drug is a prodrug of testosterone, the biological ligand of the androgen receptor (AR) and hence is an androgen and anabolic steroid.[14][9] It has strong androgenic effects and moderate anabolic effects, which make it useful for producing masculinization and suitable for androgen replacement therapy.[9] Testosterone undecanoate is a testosterone ester and a prodrug of testosterone in the body.[8][7][5] Because of this, it is considered to be a natural and bioidentical form of testosterone.[15]

Testosterone undecanoate was introduced in China for use by injection and in the European Union for use by mouth in the 1970s.[16][17] It became available for use by injection in the European Union in the early to mid 2000s and in the United States in 2014.[18][19] Formulations for use by mouth are approved in the United States.[2][3][20] Along with testosterone enanthate, testosterone cypionate, and testosterone propionate, testosterone undecanoate is one of the most widely used testosterone esters.[14][5][9] However, it has advantages over other testosterone esters in that it can be taken by mouth and in that it has a far longer duration when given by injection.[21][7][5][6][9] In addition to its medical use, testosterone undecanoate is used to improve physique and performance.[9] The drug is a controlled substance in many countries and so non-medical use is generally illicit.[9]

Oral administration of testosterone undecanoate is an effective method to achieve therapeutic physiological levels of serum testosterone in patients with hypogonadism. In addition, oral therapy has been found to have a positive impact on quality of life factors such as sexual function, mood, and mental status, as documented in various studies.[22]

Medical dosage

Testosterone undecanoate is used in androgen replacement therapy in men, including trans-men. It is specifically approved only for the treatment of hypogonadism.[23][24][25] As an intramuscular injection, it is administered at a dosage of 1,000 mg (4 mL) once every 3 months.[13] Because of rare occasions of pulmonary embolism it is not recommended to inject 4 mL of Nebido into one muscle, but to split it into two 2mL injections into left and right counter muscles (e.g. gluteals).[26]

Conversely, oral testosterone undecanoate must be taken two or three times a day with food.[13][27]

Side effects

Side effects of testosterone undecanoate include virilization among others.[9]

Anaphylaxis

The Reandron 1000 formulation (Aveed in the United States) contains 1,000 mg of testosterone undecanoate suspended in 4 ml castor oil with benzyl benzoate for solubilization and as a preservative, and is administered by intramuscular injection. As an excipient in Reandron 1000, benzyl benzoate has been reported as a cause of anaphylaxis (a serious life-threatening allergic reaction) in a case in Australia .[28] Bayer includes this report in information for health professionals and recommends that physicians "should be aware of the potential for serious allergic reactions" to preparations of this type.[29] In Australia, reports to the Adverse Drug Reactions Advisory Committee (ADRAC), which evaluates reports of adverse drug reactions for the Therapeutic Goods Administration (TGA), show several reports of allergic reactions since the anaphylaxis case from 2011.

Pharmacology

Pharmacodynamics

v · d · e Androgenic vs. anabolic activity
of androgens/anabolic steroids
Medication Ratioa
Testosterone ~1:1
Androstanolone (DHT) ~1:1
Methyltestosterone ~1:1
Methandriol ~1:1
Fluoxymesterone 1:1–1:15
Metandienone 1:1–1:8
Drostanolone 1:3–1:4
Metenolone 1:2–1:30
Oxymetholone 1:2–1:9
Oxandrolone 1:3–1:13
Stanozolol 1:1–1:30
Nandrolone 1:3–1:16
Ethylestrenol 1:2–1:19
Norethandrolone 1:1–1:20
Notes: In rodents. Footnotes: a = Ratio of androgenic to anabolic activity. Sources: See template.

Testosterone undecanoate is a prodrug of testosterone and is an androgen and anabolic–androgenic steroid (AAS). That is, it is an agonist of the androgen receptor (AR).

Pharmacokinetics

Testosterone undecanoate has a very long elimination half-life and mean residence time when given as a depot intramuscular injection.[30][5][6] Its elimination half-life is 20.9 days and its mean residence time is 34.9 days in tea seed oil, while its elimination half-life is 33.9 days and its mean residence time is 36.0 days in castor oil.[5][6] These values are substantially longer than those of testosterone enanthate (which, in castor oil, has values of 4.5 days and 8.5 days, respectively).[30] Testosterone undecanoate is administered via intramuscular injection once every three months or so.[13][31]

Chemistry

Testosterone undecanoate, or testosterone 17β-undecanoate, is a synthetic androstane steroid and a derivative of testosterone.[32][33] It is an androgen ester; specifically, it is the C17β undecylate (undecanoate) ester of testosterone.[32][33] A related testosterone ester with a similarly very long duration is testosterone buciclate.[7][8]

History

In the late 1970s, testosterone undecanoate was introduced for oral use in Europe,[16] although intramuscular testosterone undecanoate had already been in use in China for several years.[17] Intramuscular testosterone undecanoate was not introduced in Europe and the United States until much later, in the early to mid 2000s and 2014, respectively.[18][19] Testosterone undecanoate was approved in the United States only in 2014 after three previous rejections due to safety concerns.[34]

Society and culture

Generic names

Testosterone undecanoate is the generic name of the drug and its USAN and BAN.[32][33][35][36] It is also referred to as testosterone undecylate.[32][33][35][36]

Brand names

Testosterone undecanoate is or has been marketed under a variety of brand names, including Andriol, Androxon, Aveed, Cernos Depot, Jatenzo, Kyzatrex,[4] Nebido, Nebido-R, Panteston, Reandron 1000, Restandol, Sustanon 250, Undecanoate 250, and Undestor.[32][33][35][37][36]

Availability

Oral testosterone undecanoate is available in Europe, Mexico, Asia, and in the United States.[38][39]

Intramuscular testosterone undecanoate has approved in over 100 countries worldwide,[38][9] including European Union, Russia and the USA.[9][38][40] Intramuscular testosterone undecanoate is marketed most commonly as Nebido in Europe and as Aveed in the United States while oral testosterone undecanoate is marketed most commonly as Andriol.[9][38][40] However, as of 2023 Nebido is not on the formulary of most US hospitals, due to several incidents of pulmonary embolism that have been reported in the country.

Legal status

Testosterone undecanoate, along with other AAS, is a schedule III controlled substance in the United States under the Controlled Substances Act and a schedule IV controlled substance in Canada under the Controlled Drugs and Substances Act.[41][42]

In March 2019, the US Food and Drug Administration approved testosterone undecanoate (Jatenzo), an oral testosterone capsule to treat men with certain forms of hypogonadism. These men have low testosterone levels due to specific medical conditions, such as genetic disorders like Klinefelter syndrome or tumors that have damaged the pituitary gland.[20] The FDA granted the approval of Jatenzo to Clarus Therapeutics.[20][43]

In March 2022, testosterone undecanoate (Tlando) was approved for medical use in the United States.[3]

In July 2022, Kyzatrex, an oral testosterone undecanoate capsule, was approved for medical use in the United States.[4] The FDA granted the approval of Kyzatrex to Marius Pharmaceuticals.[44]

Research

Non-alcoholic steatohepatitis

In 2013, a phase II clinical trial testing intramuscular testosterone undecanoate for the treatment of non-alcoholic steatohepatitis (NASH) was initiated in the United Kingdom .[45] In the United States in 2018, Lipocine Inc. began investigating the potential of using an oral testosterone undecanoate formulation, known as LPCN-1144, in patients with NASH.[46]

Osteoporosis

In 2013, a study aimed to evaluate the efficacy of testosterone undecanoate therapy on bone mineral density (BMD) and biochemical markers of bone turnover in elderly males with osteoporosis and low serum testosterone levels.

They study found that administering low-dose testosterone undecanoate (TU) at a rate of 20 mg per day to elderly men with low serum testosterone and osteoporosis effectively increases bone mineral density in the lumbar spine and femoral neck, and improves bone turnover, similar to the standard-dose TU (40 mg, per day) treatment. The treatment did not exhibit any adverse side effects on the prostate gland, including prostate-specific antigen. Therefore, low-dose TU appears to be a safe and cost-effective protocol for treating elderly male osteoporosis.[47] However, further clinical trials with larger sample sizes, multiple centers, and long-term follow-ups are required to determine the efficacy and safety of low-dose testosterone undecanoate treatment in elderly male osteoporosis with low serum testosterone.

Health implications

Body composition

In 2020, a study that evaluated the effects of testosterone therapy in men with testosterone deficiency and varying degrees of weight (normal weight, overweight, and obesity) on anthropometric and metabolic parameters found that long-term testosterone undecanoate therapy in hypogonadal men, regardless of their weight at the start of the study, led to improvements in several body composition parameters, including body weight, waist circumference, and body mass index. Additionally, testosterone undecanoate therapy was found to lower fasting blood glucose and HbA1c levels and improve lipid profiles in this population.[48]

Bone density

There have been several studies that evaluate the effect of testosterone therapy on bone density or bone mineral density (BMD). One study concluded that long-term testosterone replacement therapy (TRT) in middle-aged men with late-onset hypogonadism (LOH) and metabolic syndrome (MS) led to a significant increase in both vertebral and femoral bone mineral density (BMD) after 36 months of treatment, as measured by dual-energy x-ray absorptiometry. The TRT treatment was shown to induce a 5% per year increase in BMD without changes in body mass index (BMI). The study suggests that long-term TRT could be beneficial for improving bone health in middle-aged men with LOH and MS, even in the absence of osteoporosis.[49]

References

  1. ↑ "Testosterone Use During Pregnancy". 20 August 2019. https://www.drugs.com/pregnancy/testosterone.html. 
  2. ↑ 2.0 2.1 "Jatenzo- testosterone undecanoate capsule, liquid filled". 11 January 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ed7b5d41-7475-4c10-99b9-b62b3434ae60. 
  3. ↑ 3.0 3.1 3.2 "Tlando- testosterone undecanoate capsule, liquid filled". 28 March 2022. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=479b55bd-2023-486a-8922-3b1de48b935c. 
  4. ↑ 4.0 4.1 4.2 "Kyzatrex- testosterone undecanoate capsule, liquid filled". 18 October 2022. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7f7167a7-2a25-47e2-acf5-33f499fce971. 
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Andrology: Male Reproductive Health and Dysfunction. Springer Science & Business Media. 13 January 2010. pp. 441–446. ISBN 978-3-540-78355-8. https://books.google.com/books?id=mEgckDNkonUC&pg=PA441. 
  6. ↑ 6.0 6.1 6.2 6.3 6.4 "Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: phase I studies". European Journal of Endocrinology 140 (5): 414–419. May 1999. doi:10.1530/eje.0.1400414. PMID 10229906. 
  7. ↑ 7.0 7.1 7.2 7.3 Testosterone: Action, Deficiency, Substitution. Cambridge University Press. 26 July 2012. pp. 313–315, 321–322. ISBN 978-1-107-01290-5. https://books.google.com/books?id=MkrAPaQ4wJkC&pg=PA315. Retrieved 3 January 2018. 
  8. ↑ 8.0 8.1 8.2 Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. 2001. pp. 1185–. ISBN 978-0-7817-1750-2. https://books.google.com/books?id=FVfzRvaucq8C&pg=PA1185. Retrieved 2018-01-03. 
  9. ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 Anabolics. Molecular Nutrition LLC. 2011. pp. 180–182, 331–334. ISBN 978-0-9828280-1-4. https://books.google.com/books?id=afKLA-6wW0oC&pg=PT180. Retrieved 2018-01-03. 
  10. ↑ "Testosterone therapy for transgender men". The Lancet. Diabetes & Endocrinology 5 (4): 301–311. April 2017. doi:10.1016/S2213-8587(16)00036-X. PMID 27084565. 
  11. ↑ "Long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals". The Journal of Sexual Medicine 4 (5): 1479–1484. September 2007. doi:10.1111/j.1743-6109.2007.00556.x. PMID 17635694. 
  12. ↑ "Safety aspects of 36 months of administration of long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals". European Journal of Endocrinology 161 (5): 795–798. November 2009. doi:10.1530/EJE-09-0412. PMID 19749027. 
  13. ↑ 13.0 13.1 13.2 13.3 New Concepts for Human Disorders of Sexual Development. S. Karger AG. 28 September 2010. pp. 256–. ISBN 978-3-8055-9569-8. https://books.google.com/books?id=CQhaAgAAQBAJ&pg=PA256. Retrieved 3 November 2016. 
  14. ↑ 14.0 14.1 "Pharmacology of anabolic steroids". British Journal of Pharmacology 154 (3): 502–521. June 2008. doi:10.1038/bjp.2008.165. PMID 18500378. 
  15. ↑ "Compounded Bioidentical Hormones in Endocrinology Practice: An Endocrine Society Scientific Statement". The Journal of Clinical Endocrinology and Metabolism 101 (4): 1318–1343. April 2016. doi:10.1210/jc.2016-1271. PMID 27032319. 
  16. ↑ 16.0 16.1 Testosterone Dreams: Rejuvenation, Aphrodisia, Doping. University of California Press. 21 February 2005. pp. 134–. ISBN 978-0-520-93978-3. https://archive.org/details/testosteronedrea00hobe. 
  17. ↑ 17.0 17.1 The Scientific Basis of Urology. CRC Press. 26 July 2010. pp. 294–. ISBN 978-1-84184-749-8. https://books.google.com/books?id=h6HSBQAAQBAJ&pg=PA294. Retrieved 27 October 2017. 
  18. ↑ 18.0 18.1 Williams Textbook of Endocrinology. Elsevier Health Sciences. 11 November 2015. pp. 709, 711, 765. ISBN 978-0-323-34157-8. https://books.google.com/books?id=iPIACwAAQBAJ&pg=PA709. Retrieved 27 October 2017. 
  19. ↑ 19.0 19.1 "Testosterone Undecanoate-Schering AG". Drugs in R&D 5 (6): 368–369. 2004. doi:10.2165/00126839-200405060-00012. PMID 15563244. 
  20. ↑ 20.0 20.1 20.2 Meyer L (27 March 2019). "FDA approves new oral testosterone capsule for treatment of men with certain forms of hypogonadism" (Press release). U.S. Food and Drug Administration (FDA). Archived from the original on 7 September 2020. Retrieved 27 August 2020.
  21. ↑ "A new oral testosterone undecanoate formulation". World Journal of Urology 21 (5): 311–315. November 2003. doi:10.1007/s00345-003-0372-x. PMID 14579074. 
  22. ↑ Ahmad, Syed W et al. “Is Oral Testosterone the New Frontier of Testosterone Replacement Therapy?.” Cureus vol. 14,8 e27796. 8 Aug. 2022, doi:10.7759/cureus.27796
  23. ↑ "Testosterone undecanoate depot injection". AdisInsight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800017041. 
  24. ↑ "Testosterone undecanoate - Organon". AdisInsight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800011489. 
  25. ↑ "Aveed- testosterone undecanoate injection". 23 August 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f80f025b-17d8-40af-8739-20ce07902045. 
  26. ↑ https://www.bayer.com/sites/default/files/NEBIDO_EN_PIL.pdf
  27. ↑ Pharmacology, Doping and Sports: A Scientific Guide for Athletes, Coaches, Physicians, Scientists and Administrators. Routledge. 27 October 2008. p. 25. ISBN 978-1-134-08880-5. https://books.google.com/books?id=nV3kDPoek5kC&pg=PA25. Retrieved 3 November 2016. 
  28. ↑ "Anaphylaxis triggered by benzyl benzoate in a preparation of depot testosterone undecanoate". Case Reports in Medicine 2012: 384054. 2012. doi:10.1155/2012/384054. 384054. PMID 22272209. 
  29. ↑ "Nebido Monograph – Information for Health Care Professionals". Bayer. 2016. http://www.nebido.com/en/hcp/product-information/nebido-monograph/index.php. 
  30. ↑ 30.0 30.1 The Leydig Cell in Health and Disease. Springer Science & Business Media. 28 October 2007. pp. 423–. ISBN 978-1-59745-453-7. https://books.google.com/books?id=x4ttqKIAOg0C&pg=PA423. Retrieved 6 October 2016. 
  31. ↑ Medical Care of Cancer Patients. PMPH-USA. 2009. pp. 247–. ISBN 978-1-60795-008-0. https://books.google.com/books?id=XxfjqF1A0TkC&pg=PA247. Retrieved 2017-10-30. 
  32. ↑ 32.0 32.1 32.2 32.3 32.4 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 641–642. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA641. Retrieved 6 October 2016. 
  33. ↑ 33.0 33.1 33.2 33.3 33.4 Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 1002–1004. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA1002. Retrieved 2017-12-13. 
  34. ↑ "FDA Approves Aveed Testosterone Jab, with Restrictions". March 7, 2014. http://www.medscape.com/viewarticle/821632. 
  35. ↑ 35.0 35.1 35.2 Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 6 December 2012. ISBN 978-94-011-4439-1. https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA270. Retrieved 6 October 2016. 
  36. ↑ 36.0 36.1 36.2 "Testosterone". https://www.drugs.com/international/testosterone.html. 
  37. ↑ "Testosterone undecanoate profile and most popular brands in USA". http://downsizefitness.com/rankings/testosterone-undecanoate/. 
  38. ↑ 38.0 38.1 38.2 38.3 "The History of Testosterone and the Testes: From Antiquity to Modern Times". Testosterone. Springer. 2017. pp. 1–19. doi:10.1007/978-3-319-46086-4_1. ISBN 978-3-319-46084-0. 
  39. ↑ Hormones, Brain and Behavior, Five-Volume Set. Academic Press. 10 June 2002. pp. 20–. ISBN 978-0-12-532104-4. https://books.google.com/books?id=cGbE2nC__Q0C&pg=PA20. Retrieved 27 October 2017. 
  40. ↑ 40.0 40.1 "Drug Product Database - Health Canada". Health Canada. 2010-03-18. http://www.hc-sc.gc.ca/dhp-mps/prodpharma/databasdon/index-eng.php. 
  41. ↑ Drug Abuse Handbook, Second Edition. CRC Press. 21 December 2006. pp. 30–. ISBN 978-1-4200-0346-8. https://books.google.com/books?id=ZjrMBQAAQBAJ&pg=PA30. Retrieved 11 November 2017. 
  42. ↑ Pharmacology for Canadian Health Care Practice. Elsevier Health Sciences. 5 August 2016. p. 50. ISBN 978-1-77172-066-3. https://books.google.com/books?id=dNgoDwAAQBAJ&pg=PA50. Retrieved 11 November 2017. 
  43. ↑ "Clarus Therapeutics Receives U.S. FDA Approval of Jatenzo (Testosterone Undecanoate Capsules for Oral Use) (CIII) for Testosterone Replacement Therapy in Certain Adult Men". http://clarustherapeutics.com/content/investors-and-media/releases/clarus-receives-fda-approval-of-jatenzo.htm. 
  44. ↑ "Kyzatrex (testosterone undecanoate) FDA Approval History". https://www.drugs.com/history/kyzatrex.html. 
  45. ↑ Pilot Open Study of Testosterone Replacement in Non-alcoholic Steatohepatitis. 25 April 2017. https://clinicaltrials.gov/ct2/show/NCT01919294. Retrieved 14 March 2022. 
  46. ↑ "Lipocine Inc. - Clinical Trials". https://www.lipocine.com/pipeline/lpcn-1144/clinical-trials.htm. 
  47. ↑ "Effects of low-dose testosterone undecanoate treatment on bone mineral density and bone turnover markers in elderly male osteoporosis with low serum testosterone". International Journal of Endocrinology 2013: 570413. 2013. doi:10.1155/2013/570413. PMID 23533404. 
  48. ↑ "Differential effects of 11 years of long-term injectable testosterone undecanoate therapy on anthropometric and metabolic parameters in hypogonadal men with normal weight, overweight and obesity in comparison with untreated controls: real-world data from a controlled registry study". International Journal of Obesity 44 (6): 1264–1278. June 2020. doi:10.1038/s41366-019-0517-7. PMID 32060355. 
  49. ↑ "Effects of long-acting testosterone undecanoate on bone mineral density in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 36 months controlled study". The Aging Male 15 (2): 96–102. June 2012. doi:10.3109/13685538.2011.631230. PMID 22439807. 

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