Biology:P2RY2

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.[1][2]

The product of this gene, P2Y2 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.[3]

See also

References

  1. "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy". Proc Natl Acad Sci USA 91 (8): 3275–9. May 1994. doi:10.1073/pnas.91.8.3275. PMID 8159738. Bibcode1994PNAS...91.3275P. 
  2. "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family". Genomics 44 (1): 127–30. Nov 1997. doi:10.1006/geno.1997.4841. PMID 9286708. 
  3. "Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5029. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.